Institute of Celular Biology and Pathology "Nicolae Simionescu"
Looking for Partnership Looking for Extra EU Funds
Lipid metabolism in health and disease (dyslipidemia in diabetes, atherosclerosis and obesity): cellular and molecular biology of lipoproteins (Lp), dysfunctional HDL, entero-hepatic metabolism of Lp, in vivo and in vitro modification of LDL, transport of Lp across the vascular endothelium, interaction of Lp with the cells of the arterial wall, cellular cholesterol efflux, implication in atheroma formation.
Cellular biology and biochemistry of blood vessels: heart and cardiac valves in pathological conditions, biochemical and biophysical modifications in atherogenesis, diabetes and obesity, experimental animal models of atherosclerosis.
Novel biomarkers for coronary artery disease vulnerability: oxidized lipids, Lp-associated enzymes, inflammatory mediators, circulating miRNAs.
Genetic mechanisms of atherosclerosis: in vitro and in vivo functional analysis of non-coding RNAs (miRNAs), identification and validation of specific miRNAs target genes, gene polymorphisms.