Topic Description Specific Challenge: A key challenge of any research funding scheme is to ensure that significant results, outputs and/or data generated during the lifetime of a project remain available to be further exploited for maximum beneficial impact after the project finishes. Often, important scientific results reach the public domain via publication in relevant scientific journals. ...

Specific Challenge: The action generated by this topic will be part of the Remote Assessment of Disease and Relapse (RADAR) programme. The RADAR programme aims to test if new pre-emptive therapeutic development and clinical care strategies based on remote continuous monitoring are both scientifically feasible and also practically feasible as part of a wider healthcare system. Early stages of ...

Specific Challenge: Since 2008, numerous IMI consortia have been generating results in a diverse set of biomedical domains. In many projects these results have been stored in a custom database, sufficient for the project itself but difficult to access by scientists outside the project. The same is true for many internal industry research and development databases. Making a significant portio ...

Specific Challenge: Currently, published data from placebo-controlled and adequately powered clinical trials in primary Sjögren’s Syndrome (pSS) are scarce. Although specific novel, validated treatment outcome measures have been developed recently, e.g. the European League against Rheumatism (EULAR) Sjögren’s syndrome disease activity index (ESSDAI) and EULAR Sjögren’s syndrome patient reported ...

Specific Challenge: Healthcare data are very fragmented. Even data within one healthcare centre are typically spread across different repositories. Across entities, different standards are used to code diagnosis, lab results, drugs or procedures. In most healthcare systems, a majority of the core clinical data is buried in unstructured (text) notes, making data analysis even more challenging. ...

Specific Challenge: Due to the demographic situation, the older population augments in size every year. Older people are more vulnerable to infectious diseases because their immune system becomes weaker with age. The consequences are that one may observe an increasing burden of infections in the elderly with a high transmission rate. They are often treated with antibiotics causing resistance. I ...

Specific Challenge: Several challenges have yet to be addressed to better understand the role and alterations of the Blood Brain Barrier (BBB) and transport mechanisms in health and diseases. This is particularly critical for neurodegenerative diseases (e.g. Alzheimer and Parkinson’s diseases, Amyotrophic Lateral Sclerosis (ALS)), vascular dementia, multiple sclerosis and metabolism-related cen ...

Specific Challenge: The translation of novel biological concepts into drug discovery projects critically requires chemical matter that has the potential to become a valuable tool in the treatment of a disease. One of the key barriers to this translation is access to high-quality compound libraries and high throughput screening facilities, especially to academic groups and SMEs Scope: The ...

Specific Challenge: The translation of novel biological concepts into drug discovery projects critically requires chemical matter that has the potential to become a valuable tool in the treatment of a disease. One of the key barriers to this translation is access to high-quality compound libraries and high throughput screening facilities, especially to academic groups and SMEs Scope: The ...

Specific Challenge: Several challenges have yet to be addressed to better understand the role and alterations of the Blood Brain Barrier (BBB) and transport mechanisms in health and diseases. This is particularly critical for neurodegenerative diseases (e.g. Alzheimer and Parkinson’s diseases, Amyotrophic Lateral Sclerosis (ALS)), vascular dementia, multiple sclerosis and metabolism-related cen ...

Specific Challenge: Due to the demographic situation, the older population augments in size every year. Older people are more vulnerable to infectious diseases because their immune system becomes weaker with age. The consequences are that one may observe an increasing burden of infections in the elderly with a high transmission rate. They are often treated with antibiotics causing resistance. I ...

Specific Challenge: Healthcare data are very fragmented. Even data within one healthcare centre are typically spread across different repositories. Across entities, different standards are used to code diagnosis, lab results, drugs or procedures. In most healthcare systems, a majority of the core clinical data is buried in unstructured (text) notes, making data analysis even more challenging. ...