Search for European Projects

24 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Anti-tick Vaccines to Prevent Tick-borne Diseases in Europe (ANTIDotE)

Start date: Dec 1, 2013, End date: Nov 30, 2018,

Background Ixodes ricinus transmits bacterial, protozoal and viral pathogens that cause Lyme borreliosis, babesiosis and tick-borne encephalitis respectively and exceedingly affect Central and Eastern Europe (CEE). During feeding, ticks introduce salivary proteins in the skin that interfere with host defense mechanisms. However, in animals repeated tick infestations as well as vaccination against ...
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 8

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Metabolic requirements for prostate cancer cell fitness (CancerMetab)

Start date: Nov 1, 2013, End date: Oct 31, 2018,

The actual view of cellular transformation and cancer progression supports the notion that cancer cells must undergo metabolic reprogramming in order to survive in a hostile environment. This field has experienced a renaissance in recent years, with the discovery of cancer genes regulating metabolic homeostasis, in turn being accepted as an emergent hallmark of cancer. Prostate cancer presents one ...
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 1

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Unravelling the Nascent Code: Signals sensed and transmitted by the nascent chain to acquire its functional state or reprogram gene expression (THE NASCENT CODE)

Start date: Jul 14, 2014, End date: Jul 13, 2018,

"Emerging biochemical and biophysical data strongly suggest that the transformation of the potential set of proteins, encrypted in the genome, into its actual vital functional set, is a manifestation not just of the genetic code, but of an additional layer of information encoded within the newly synthesized polypeptide nascent chain. To date, we know that immediately upon the first steps of protei ...
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 1

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Hierarchical Functionalization of Graphene for Multiple device fabrication (HIGRAPHEN)

Start date: Mar 1, 2014, End date: Feb 28, 2018,

"This project is based on the application of layer-by-layer (LbL) technology for the development of a versatile and generic procedure for the fabrication of hybrid devices involving graphene and materials of a different nature such as polymeric, organic, and inorganic entities. The project aims to achieve the organization and integration of graphene sheets with heterogeneous components of differ ...
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 2

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Nanotherapeutics to Treat Antibiotic Resistant Gram-Negative Pneumonia Infections (PNEUMONP)

Start date: Jan 1, 2014, End date: Dec 31, 2017,

The main objective of PneumoNP is the development of a theragnostic system for the treatment of lung Gram-negative bacterial infections. As a proof of concept PneumoNP will focus the attention on Klebsiella pneumoniae caused infections. A diagnostic kit will be developed to enable a rapid and precise identification of the bacteria strain causing the infection and avoid the use of wide spectrum a ...
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 11

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Biomolecular Hydrogels – from Supramolecular Organization and Dynamics to Biological Function (JELLY)

Start date: Dec 1, 2012, End date: Nov 30, 2017,

Certain proteins and glycans self-organize in vivo into soft and strongly hydrated, dynamic and gel-like supramolecular assemblies. Among such biomolecular hydrogels are the jelly-like matrix that is formed around the egg during ovulation, mucosal membranes, slimy coats produced by bacteria in biofilms, and the nuclear pore permeability barrier.Even though biomolecular hydrogels play crucial roles ...
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 2

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Design of a versatile and fast colloidal sensor based on virus modified particles (VIROMA)

Start date: Nov 1, 2013, End date: Oct 31, 2017,

"Viroma project aims to fabricate multiplexed bead-based arrays as sensing devices on the basis of virus capsid and virosome Layer by Layer-assisted assembly on colloidal carriers. The virosome based platform technology will be suitable for the detection of several analytes ranging from comparatively small molecules, of the size of dioxins to larger biomolecules such as small proteins. Such syst ...
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 4

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Biological Foundation for the Safety Classification of Engineered Nanomaterials (ENM): Systems Biology Approaches to Understand Interactions of ENM with Living Organisms and the Environment (NANOSOLUTIONS)

Start date: Apr 1, 2013, End date: Mar 31, 2017,

The main objective of this research proposal is to identify and elaborate those characteristics of ENM that determine their biological hazard potential. This potential includes the ability of ENM to induce damage at the cellular, tissue, or organism levels by interacting with cellular structures leading to impairment of key cellular functions. These adverse effects may be mediated by ENM-induced a ...
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 40

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Development of plasmonic quorum sensors for understanding bacterial-eukaryotic cell relations (PLASMAQUO)

Start date: Mar 1, 2011, End date: Feb 28, 2017,

"This proposal aims at the development of novel nanostructured materials based on crystalline assemblies of anisotropic plasmonic (gold/silver) nanoparticles, to be used for the surface enhanced Raman scattering (SERS) detection of quorum sensing (QS) signaling molecules, and to the demonstration of applications of such materials to monitor population kinetics in bacterial colonies and the determi ...
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 2

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Novel Upconversion Nanomaterials for Inorganic Photoactivated Chemotherapy (UCnanomat4iPACT)

Start date: Jan 15, 2013, End date: Jan 14, 2017,

Upconversion nanoparticles (UCNPs) have outstanding optical and magnetic properties, which make them extremely suited for application in cancer phototherapy and imaging. They efficiently convert low energy near infrared (NIR) light to higher energies in the visible. The so-generated upconverted luminescence can be exploited to photoactive anticancer metal complexes, a promising class of compounds ...
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 1

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Translocation and Safe Design of Surface Engineered Metal oxide Nanoparticles (BRASINOEU)

Start date: Jan 1, 2013, End date: Dec 31, 2016,

"BRASINOEU aims to study the translocation and nanosafety issues of engineered metal oxide nanoparticles (NPs).The new scientific and technology developments of nanotechnology require a deeper knowledge of the effects of nanotechnology based products on human health. This knowledge is fundamental for the development of nanotechnology and to achieve its full acceptance. The concept of “safe by desi ...
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 7

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Self-Assembly in Confined Space (SACS)

Start date: Nov 1, 2012, End date: Oct 31, 2016,

Supramolecular chemistry studies chemistry beyond individual molecules, where molecules or macromolecules form larger entities by spontaneous self-assembly or by self-organisation. The resulting supramolecular architectures are held together by covalent bonds and a variety of non-covalent intermolecular interactions (hydrogen bonding, metal coordination, hydrophobic interactions etc). Spatially, t ...
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 10

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Innovative Radiochemistry to Advance Molecular Imaging (RADIOMI)

Start date: Nov 1, 2012, End date: Oct 31, 2016,

The RADIOMI Initial Training Network (ITN) has the goal of providing training in a superbly suited academic and industrial environment uniquely equipped to conduct a scientific research program that addresses one of the key aspects of functional imaging, the underpinning radiochemistry essential for preparation of radiotracers currently difficult or not possible to access. This will be exploited f ...
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 9

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Implication of energy sensing pathways in prostate cancer biology (PTENLKB1)

Start date: Jan 2, 2012, End date: Jan 1, 2016,

"Prostate cancer is among the most prevalent forms of cancer in men and the fifth cause of dead from cancer in men worldwide. Therefore, the understanding of prostate cancer biology is a key step in the development of new effective therapeutic approaches. In this line, the use of genetically engineered mouse models has been critical in the understanding of the genetic cues that regulate the proces ...
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 1

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European Soft Matter Infrastructure (ESMI)

Start date: Jan 1, 2011, End date: Dec 31, 2015,

The central objective of this ESMI proposal is to create a top-level interdisciplinary research infrastructure available to a broad European materials research community. This is of crucial importance to the EU in view of the European strategy for nanosciences and nanotechnology and its implementation report that identifies “a lack of leading interdisciplinary infrastructures”.ESMI offers the mos ...
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 18

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Self-assembled virus-like vectors for stem cell phenotyping (SAVVY)

Start date: Jan 1, 2013, End date: Dec 31, 2015,

The Self-Assembled Virus-like Vectors for Stem Cell Phenotyping (SAVVY) project relies on hierarchical, multi-scale assembly of intrinsically dissimilar nanoparticles to develop novel types of multifunctional Raman probes for analysis and phenotyping of heterogeneous stem cell populations.Our project will address a large unmet need, as stem cells have great potential for a broad range of therapeut ...
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 8

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European Research Training in the Ubiquitin Proteasome System (UPStream)

Start date: Nov 1, 2011, End date: Oct 31, 2015,

The main objective of the international training network UPStream is the training of a novel generation of European scientist in a critical and complex field of modern biology: the understanding of the regulation of the UPS and its potential use for drug development. The importance of this process is illustrated by the imperious necessity to destroy certain proteins during several phases of the ce ...
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 10

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A pan-European infrastructure for quality in nanomaterials safety testing (QUALITYNANO)

Start date: Feb 1, 2011, End date: Jul 31, 2015,

Nanoscale objects interact with living organisms in a fundamentally new manner, ensuring that a fruitful marriage of nanotechnology and biology will long outlast short term imperatives. Therefore, investment in an infrastructure to drive scientific knowledge of the highest quality will have both immediate benefits of supporting the safety assessment of legacy nanomaterials, as well as pointing tow ...
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 33

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Combined Highly Active Anti-retroviral Microbicides (CHAARM)

Start date: Jan 1, 2010, End date: Jun 30, 2015,

This proposal is for a large scale collaborative project in which we propose both to develop novel microbicides directed against new intracellular targets and to investigate novel combinations of highly active anti-retroviral drugs which may be particularly effective as microbicides. Combinations may enhance efficacy but equally importantly will increase the genetic barrier to the development of r ...
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 34

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"Combining supramolecular chemistry, physico-chemical characterization and theoretical modeling to understand multivalent interactions at the cell-hyaluronan matrix interface" (CELLMULTIVINT)

Start date: Mar 15, 2012, End date: Mar 14, 2015,

"Multivalent interactions are characterized by the simultaneous binding of multiple ligands on one entity to multiple receptors on another. Multivalency provides the basis for mechanisms of both agonizing and antagonizing biological interactions that are fundamentally different from those available in monovalent systems. Even though multivalent interactions occur broadly in biological systems, the ...
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 1

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A Modular Nanosystems Platform for Advanced Cancer Management: Nano-vehicles; Tumor Targeting and Penetration Agents; Molecular Imaging, Degradome based Therapy (SAVEME)

Start date: Mar 1, 2011, End date: Feb 28, 2015,

SaveMe project will address current urgent needs for pancreatic cancer diagnosis and treatment by exploiting partners’ expertise and most recent research achievements for the design and development of novel modular nanosystems platform integrating new functionalized nano-core particles and active agents. The modular platform will enable the design of diverse active nanosystems per diagnostic or th ...
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 23

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The nuclear pore permeability barrier – physical concepts and a biosynthetic approach to understand and exploit the unique selectivity of a natural macromolecular sieve (Nuclear Pore)

Start date: Mar 1, 2013, End date: Feb 28, 2015,

Nuclear pore complexes (NPCs) are the exclusive gate of entry/exit of macromolecules into and out of the nucleus of living cells. They exhibit a unique selectivity in transport, with respect to size and molecular species: very small molecules can diffuse efficiently through the pore, while larger objects are delayed/blocked unless they are bound to specialized proteins, so called nuclear transport ...
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 1

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Regenerable active polyelectrolyte nanofiltration membranes for water reuse and metal/acid recovery (LbLBRANE)

Start date: Feb 1, 2012, End date: Jan 31, 2015,

The shortage of drinking water in many regions on the planet constitutes a real problem and hazard. The use of seawater, brackish water and wastewater for human consumption is not a new concept. In spite of the success of membrane technology in water reclamation, membrane separation systems suffer from a serious problem: membrane fouling. The main downside is an inevitabe increase in operation and ...
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 13

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Integration of Novel Nanoparticle based Technology for Therapeutics and Diagnosis of different types of Cancer (NANOTHER)

Start date: Sep 1, 2008, End date: Aug 31, 2012,

The breakthrough objective of NANOTHER is to develop & characterise a novel nanoparticle system that will be used as a therapeutic agent or diagnosis tool for breast cancer, colorectal cancer & bone metastasis. Theranostics, the development of nanoparticles with both functionalities, will also be carried out using the hyperthermic effect to kill tumour cells or to release the selected drug . The n ...
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 19