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Over 40 European Projects Found

Searched on 125080 European Projects

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NUCLEUS - New Understanding of Communication, Learning and Engagement in Universities and Scientific Institutions (NUCLEUS)

Start date: Sep 1, 2015, End date: Aug 31, 2019,

NUCLEUS develops, supports and implements inclusive and sustainable approaches to Responsible Research and Innovation within the governance and culture of research organisations in Europe. A major goal of the transdisciplinary project will be to stimulate research and innovation which continuously reflects and responds to societal needs.In order to achieve a multifaceted and cross-cultural New Und ...
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 24

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The Fingerprint of a Galactic Nucleus: A Multi-Wavelength, High-Angular Resolution, Near-Infrared Study of the Centre of the Milky Way (GALACTICNUCLEUS)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

...lusters, the densest and most massive star clusters in the present-day Universe. Their formation is still an unresolved puzzle. The centre of the Milky Way contains a massive black hole and a stellar nucleus and is orders of magnitude closer than any comparable target. It is the only galactic nucleus and the most extreme astrophysical environment that we can examine on scales of milli-parsecs. It ...
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Synaptic integration in the ventromedial hypothalamic nucleus in aggressive behaviour (ZPVMH)

Start date: Jun 1, 2015, End date: May 31, 2017,

...The aim of this project is to determine mechanisms of synaptic integration in a circuit underlying aggressive behaviour in the mouse, and analyse how single neurons in the ventromedial hypothalamic nucleus (VMH) contribute to computations leading to aggressive behaviour. By combining behavioural, genetic, electrophysiological and optical techniques, this project will determine: (i) the biophysical ...
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 1

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Disarming bacterial weapons in the nucleus: functional study of Chlamydia nuclear effectors (NUChLEAR)

Start date: Jul 1, 2012, End date: Jun 30, 2017,

...urrent treatments fail to erradicate the resulting chronic infections.Our project is focused on the bacterial proteins that are secreted into the host cell during infection and translocate into the nucleus. Our preliminary work has already identified some of these “nuclear effectors” of Chlamydia. Targetting the “central system” of the host, these proteins are likely essential for infection. We wi ...
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 1

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Biomimetic nano-fiber-based nucleus pulposus regeneration for the treatment of degenerative disc disease (NPMimetic)

Start date: Feb 1, 2011, End date: Jan 31, 2015,

"The intervertebral discs form the elastic part of the spine. It is composed of the annulus fibrosus, a tough outer layer of fibrocartilage, surrounding an elastic gelatinous core, the nucleus pulposus (NP). With age, the water content of the NP decreases, thus, the mechanical loads concentrate on the annulus. This leads to the NP wear, and cracking with a subsequent inflammation reaction and a pr ...
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 12

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An innovative system to impose altered features on a defined chromosome region and investigate its movement by fluorescence microscopy in the nucleus of a cell (Chromatin motility)

Start date: May 1, 2009, End date: Apr 30, 2011,

...ased economy and society. Scientifically, the project involves cutting-edge microscopy in fission yeast to characterize the relationship between different chromatin features and their position in the nucleus. We will integrate distinct scientific approaches to obtain breakthroughs in the field. All research activities are in compliance with fundamental ethical principles. Further the project will ...
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Plasma membrane to nucleus trafficking of the transcriptional co-activator BRX - characterization of a novel hormone signaling pathway in plants (BRXTRAFFIC)

Start date: Sep 1, 2009, End date: Aug 31, 2011,

...ys. Nevertheless, additional, conceptually different pathways very likely remain to be discovered. A recent example for a conceptually novel pathway is the perception of the phytohormone auxin in the nucleus by direct binding to and regulation of a certain class of E3 ubiquitin ligases, the auxin receptors . Auxin is of pivotal importance in various processes of plant development throughout the li ...
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 1

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REwiring the nucleus TowaRds plant ImmuNity (RETRaIN)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

...that manipulate the host defense circuitry to suppress immunity and promote virulence. Interestingly, many of the processes that determine immunity or susceptible interactions, take place in the host nucleus. With the identification of vast repertoires of (nuclear) secreted pathogen proteins (effectors) and host signaling components that extert their functions in the nucleus, this host compartment ...
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A consumer oriented prototype – forming the nucleus of a novel Ecological Accounting System (MYECOCOST)

Start date: Oct 15, 2012, End date: Oct 14, 2015,

myEcoCost is a foundational methodology that defines a global collaborative network of resource accounting nodes. It provides a means of accounting for and expressing usage of natural resources for products, services and technologies, to inform all economic actors including SMEs (Small and Medium size Enterprise) and consumers, on environmentally relevant information. It is a novel, bottom up appr ...
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Synaptic plasticity and long-term depression in the nucleus accumbens after in vivo exposure to addictive drugs (SPAR)

Start date: Dec 1, 2007, End date: Nov 30, 2009,

Consumption of addictive drugs causes changes in the brain areas involved in rewarding behaviours that are essential to an animal's survival and adaptation. One of these areas is the nucleus accumbens. Normally occurring synaptic plasticity in the nucleus accumbens; such as a long-term decrease in synaptic strength mediated by cannabinoids (long-term depression); can change after brief or chronic ...
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Positioning the nucleus for cell migration and muscle fiber function (PhONICs)

Start date: Jul 1, 2014, End date: Jun 30, 2019,

The cell nucleus is positioned at specific places within the cytoplasm and this position is important for different cellular, developmental and physiological processes. Nuclear positioning depends on connections between nuclear envelope proteins and the cytoskeleton. In migrating cells, we found that the nucleus is positioned away from the front of the cell and this event is important for cell mig ...
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Investigation into the transduction of stress signals to the nucleus (ITSSN)

Start date: Jun 1, 2008, End date: May 31, 2010,

"The nucleus contains distinct sub-compartments, the composition and localisation of which change during normal physiological processes, or in response to stress or disease. The molecular stimuli that provoke these changes, and their effects on gene expression are not well characterised. This proposal aims to further define the mechanisms that underlie nuclear organisation, which is fundamentally ...
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Drug addiction: molecular changes in reward and aversion circuits (ADDICTIONCIRCUITS)

Start date: Oct 1, 2010, End date: Sep 30, 2015,

...its underlying aversion. Little is known about these circuits, but my hypothesis is that an important component of aversion is signaled by a specific neuronal population in the brainstem parabrachial nucleus, projecting to the central amygdala. We will test this hypothesis and also determine how this aversion circuit contributes to the persistence of addiction and to relapse.To dissect this compli ...
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A combined approach of cryo-electron tomography and protein tagging for elucidating the structural organization of the human Nuclear Pore Complex (NPCcryoET)

Start date: Dec 1, 2012, End date: Nov 30, 2014,

Nuclear Pore Complexes (NPCs) represent the exclusive passageway in and out of the nucleus but also function in gene regulation and nuclear organization. NPCs serve as docking sites for many viruses and were associated with several human diseases, e.g. leukemia. Understanding the nuclear transport mechanism will have a huge impact on human health research of such diseases. Multiple copies of ~30 d ...
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Maintaining the Human Mitochondrial Genome (DELMIT)

Start date: Nov 1, 2016, End date: Oct 31, 2021,

...ode for 13 of the about 90 proteins present in the respiratory chain. All proteins necessary for mtDNA replication, as well as transcription and translation of mtDNA-encoded genes, are encoded in the nucleus. Mutations in nuclear-encoded proteins required for mtDNA maintenance is an important cause of neurodegeneration and muscle diseases. The common result of these defects is either mtDNA depleti ...
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 1

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Control of cell division in Sulfolobus acidocaldarius (CCDSA)

Start date: Jan 1, 2017, End date: Dec 31, 2018,

...encing and comparative genomics to identify novel cell division regulators that are conserved in eukaryotes. We expect this detailed characterization of cell division in cells without organelles or a nucleus to have broad implications for our understanding of the origins of the more elaborate mechanisms found in extant eukaryotes. Moreover, in the future we expect the knowledge gained and interdis ...
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 1

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The physics and forensics of neutron star explosions (CSINEUTRONSTAR)

Start date: Jun 1, 2015, End date: May 31, 2020,

Neutron stars offer a unique environment in which to develop and test theories of the strong force. Densities in neutron star cores can reach up to ten times the density of a normal atomic nucleus, and the stabilizing effect of gravitational confinement permits long-timescale weak interactions. This generates matter that is neutron-rich, and opens up the possibility of stable states of strange ma ...
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Construction of a Genetic System for Planctomycetes (CoGniSePlanctomyces)

Start date: Mar 1, 2010, End date: Feb 28, 2013,

...nisms, which reproduce via budding, form cell aggregates, such as biofilms and “marine-snow”. Beside their complex lifestyle, they comprise sub cellular compartments resembling the eukaryotic nucleus which questions the pro-/eukaryotic dichometrie. Thus, they combine a complex lifestyle with interspecies communication, which is required for biofilm formation. However, in-depth analysis of Planctom ...
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 3

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Imbunatatirea calitatii educatiei prin profesionalizare internationala

Start date: Sep 1, 2014, End date: Aug 31, 2015,

...valuation methods and tools, diversified including the contribution of innovative staff or mixed teams of teachers and students. The team of teachers participating in the European mobility will be a nucleus in the local community that will disseminate and implement the knowledge and skills acquired both school level and at the local, regional and national levels. By participating in this mobility ...
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 2

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Conservation of european mink (Mustela lutreola) in Catalonia (Spain) (Visón Cataluña)

Start date: Jan 1, 2002, End date: Dec 31, 2005,

... Results This LIFE Nature project exceeded expectations on captive breeding of the ‘threatened with extinction’ European mink from its western nucleus. Although the project found that the species was now totally absent from the Catalonia region, it successfully prepared the way for its return. The project established new procedures for captive bree ...
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 2

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THE ENZYMATIC MACHINERY OF HUMAN MITOCHONDRIAL DNA MAINTENANCE (REPMIT)

Start date: Apr 1, 2011, End date: Mar 31, 2016,

...ode for 13 of the about 90 proteins present in the respiratory chain. All proteins necessary for mtDNA replication, as well as transcription and translation of mtDNA-encoded genes, are encoded in the nucleus. Mutations in nuclear-encoded proteins required for mtDNA maintenance is an important cause of neurodegeneration and muscle diseases. The common result of these defects is either mtDNA deplet ...
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 1

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Role of the chromatin architecture in the regulation of gene transcription (CHROMATRANSCRIPT)

Start date: Jan 1, 2012, End date: Dec 31, 2015,

The complex architecture displayed by the chromatin inside the nucleus of eukaryotic cells plays an important role in several key cellular processes such as the regulation of gene expression, DNA replication and DNA repair. The dynamics of this chromatin architecture remains however poorly characterized. While at “steady state” the chromatin organization is thought to be relatively stable along th ...
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 2

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Dynamics of human genome architecture in stable and transient gene expression changes (4D-GENOME)

Start date: Jun 1, 2014, End date: May 31, 2019,

The classical view of genomes as linear sequences has been replaced by a vision of nuclear organization that is both dynamic and complex, with chromosomes and genes non-randomly positioned in the nucleus. Process compartmentalization and spatial location of genes modulate the transcriptional output of the genomes. However, how the interplay between genome structure and gene regulation is establish ...
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 2

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Biomimetic nanopore for a mechanistic study of the nuclear pore complex (BioNanopore)

Start date: Jun 1, 2011, End date: May 31, 2013,

Compartmentalization of the eukaryotic genome into a nucleus necessitates nuclear import and export to achieve basic cellular processes. The nuclear pore complex (NPC) is a large (60 - 125 MDa) macromolecular structure in eukaryotic cells, where it spans the nuclear membrane and serves as the gatekeeper of nucleocytoplasmic transport. While water, ions, and small molecules can freely diffuse throu ...
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Identifying molecular mechanism responsible for spatial reorganisation of the genome during embryogenesis (IMMRSRGE)

Start date: Apr 1, 2013, End date: Mar 31, 2015,

"Spatial organisation in the nucleus is not random and it has a role in genome regulation. Large blocks of heterochromatin accumulate at the nuclear envelope and positioning of genes at the nuclear periphery correlates with gene repression. However, this organisation is not fixed and nuclear reorganisation has been described during mammalian development. In the inner cell mass of the blastocyst, c ...
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REGULATION OF NEURONAL GENE EXPRESSION THROUGH CHROMOSOME ARCHITECTURE (NGECA)

Start date: Nov 1, 2016, End date: Oct 31, 2018,

...tion of many activity-regulated genes (ARGs). There are numerous interconnected levels of gene regulation; one critical aspect relates to the three-dimensional conformation of chromosomes within the nucleus. Looping of genes to regulatory regions and to other genes is required for transcriptional activation in other cell types, but remains largely unexplored in neurons. In this proposal, I will i ...
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Optimizing Antisense Oligonucleotides for Efficient and Specific Knockdown of Nuclear Non-Coding RNA (NONCODOWN)

Start date: Jun 1, 2013, End date: May 31, 2017,

The past decade has seen a dramatic increase in discovery of noncoding RNA with functional regulatory roles in the nucleus of mammalian cells. Yet tools to manipulate these nuclear noncoding RNAs remain inadequate. This proposal will develop optimized antisense oligonucleotides for targeting and degrading structured RNAs in the nucleus. This will be carried out by using both the best of what al ...
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 1

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DISKOmice (DISKOMICE)

Start date: Sep 1, 2012, End date: Aug 30, 2016,

We hypothesize that within the intervertebral disc (IVD), a niche exists comprising the nucleus pulposus and the inner layer of the annulus fibrosus and the cartilage endplate. In the niche, two events govern successful maintenance of disc cell function: the ability of progenitor cells to provide replacement cells, and the power of this cell population for renewal. In the disc niche, environmenta ...
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Compartmentalization and dynamics of Nuclear functions (CDNF)

Start date: Sep 1, 2008, End date: May 31, 2014,

The eukaryotic genome is packaged into large-scale chromatin structures that occupy distinct domains in the nucleus and this organization is now seen as a key contributor to genome functions. Two key functions of the genome can take advantage of nuclear organization: regulated gene expression and the propagation of a stable genome. To understand these fundamental processes, we have chosen to use y ...
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How force regulates cell function: a molecular and cellular outlook (ForceRegulation)

Start date: Mar 1, 2012, End date: Feb 28, 2018,

... Finally, a comparative study of the effect of force in normal and malignant cells will be accomplished. It will be tested whether or not these pathways are involved in the expression of genes in the nucleus, and the ability of normal and malignant cells to respond to external forces and to apply forces on their substrates. Magnetic tweezers, and elastic pillars will be used here.
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Shape Coexistence and Collectivity in Atomic Nuclei (SPEDE)

Start date: Feb 1, 2012, End date: Jan 31, 2016,

"In the atomic nucleus, the interplay between single-particle motion, collectivity and pairing is seen as a rich tapestry of coexisting nuclear shapes and exotic excitations. For verifying and more detailed understanding of the shape coexistence phenomenon it is important to measure transition probabilities between the coexisting nuclear states.In the endeavour to understand the nuclear structure ...
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Bright Future for Black Vulture in Bulgaria (Vultures back to LIFE)

Start date: Jul 16, 2015, End date: Jul 15, 2022,

...ee to five agro-silvo-pastoral complexes established, arranged according to the Spanish “dehesa” style, and long-term management started at the Natura 2000 SPA site, Kotlenska Planina; A nucleus of 200 fallow deer free-ranging in one of the agro-silvo-pastoral complexes; A farmer’s union established, providing a set of benefits for the farmers (clearing of 600 ha pastures, use of a mobile ...
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Investigating the topography of nuclear phosphoinositide signalling in relation to chromatin and the genome (nuc-inositide)

Start date: Feb 25, 2015, End date: Feb 24, 2017,

...hat regulate diverse cellular functions. A combination of mono, bis and tris-phosphorylation generates seven different PIs present in various subcellular compartments and importantly found within the nucleus. Nuclear PI levels change in response to diverse stimuli such as differentiation, growth factor receptor activation, growth responses in vivo, cell cycle progression, DNA damage, and cellular ...
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Physiological characterization of PK2 in the control of fertility, and its interaction with kisspeptins (PK2-KiSS)

Start date: Apr 1, 2009, End date: Mar 31, 2012,

...uration and/or function, as loss-of-function mutations in either the receptor or the ligand lead to HH. Considering that PK2 was originally described as a circadian pacemaker from the suprachiasmatic nucleus (SCN; the central translator of the photoperiodic status to the organism) and that key aspects of reproductive function (such as the preovulatory LH surge; responsible for ovulation) are exqui ...
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Control & Automation Management of Buildings & Public Spaces in the 21st Century (Campus21)

Start date: Sep 1, 2011, End date: May 31, 2015,

...rements schemes (WP1) and (v) the development of Performance Metrics and a holistic Evaluation Concept for Systems Integration (WP2).CAMPUS 21 uses existing demonstrators and living laboratories as a nucleus for up-scaling and expanding the project scope from single building to campus scale. Three sites are used for research and validation of energy and cost savings, a university campus, a multi-p ...
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European Master of Science in Midwifery

Start date: Oct 1, 2007,

...an advanced level in their own discipline giving them the opportunity to integrate theory and practice from a wider European perspective. By bringing together midwives from different backgrounds, the nucleus of students from throughout Europe who form the first cohorts of the proposed programme will develop common goals thereby enhancing midwifery practice in their own countries and contributing t ...
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Proliferation and Migration under External Constraints (PROMICO)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

...efects and eventually to mitotic cell death. This will open a new set of targets to specifically kill dividing tumour cells.2) Discover specific mechanisms that allow migrating cells to squeeze their nucleus through narrow gaps. The nucleus has been shown to be the main physical barrier to cell migration in tissues, and two types of cells are able to migrate through narrow gaps: immune cells and m ...
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Multimodal, high-resolution modeling of the thalamus for neuroimaging studies: application to dyslexia (THALAMODEL)

Start date: Jun 1, 2015, End date: May 31, 2017,

... to what extent. In addition, the tools will be distributed as part of the software package FreeSurfer, allowing its over 10,000 worldwide users to carry out cognitive neuroscience experiments at the nucleus level, and to discover new imaging biomarkers of other diseases related to the thalamus, e.g. Alzheimer's, Parkinson's, MS and ALS.This project will allow the host to acquire knowledge in medi ...
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Role of DNA methylation in the regulation of lincRNAs in Hematological Malignancies (LincMHeM)

Start date: Sep 1, 2013, End date: Aug 31, 2016,

... mechanism that regulates these lincRNAs and the functional mechanism of the vast majority of these lincRNAs are not known, but the few that have been studied are known to exert their function in the nucleus and to be involved in chromatin remodeling and transcription regulation. The expression of lincRNAs is altered in cancer, playing an important role in the initiation, prognosis and progression ...
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Understanding small RNA-mediated transposon control at the level of chromatin in the animal germline (PIWI-Chrom)

Start date: Jul 1, 2016, End date: Jun 30, 2021,

...nterplay between the piRNA pathway and chromatin biology in Drosophila with two aims: First, we will identify the factors and investigate the processes that underlie piRNA-guided silencing in the nucleus. Our objective is to understand how recruitment of an Argonaute protein to a nascent RNA mechanistically leads to the assembly of effector proteins that govern heterochromatin formation and transc ...
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