Optimizing Antisense Oligonucleotides for Efficient and Specific Knockdown of Nuclear Non-Coding RNA
(NONCODOWN)
Start date: Jun 1, 2013,
End date: May 31, 2017
PROJECT
FINISHED
The past decade has seen a dramatic increase in discovery of noncoding RNA with functional regulatory roles in the nucleus of mammalian cells. Yet tools to manipulate these nuclear noncoding RNAs remain inadequate. This proposal will develop optimized antisense oligonucleotides for targeting and degrading structured RNAs in the nucleus. This will be carried out by using both the best of what already exists in the field of nucleic acid chemistry (e.g. locked nucleic acid and the gapmer approach) and innovative new designs (e.g. CuAAC-derived PNA-DNA-LNA chimeric oligomers for degrading structured RNA targets).
Get Access to the 1st Network for European Cooperation
Log In
or
Create an account
to see this content
Coordinator
UNIVERSITY OF SOUTHAMPTON
€ 100 000,00- Yan Qiao
- Highfield SO17 1BJ SOUTHAMPTON (United Kingdom)
Details
- 100% € 100 000,00
-
FP7-PEOPLE
- Project on CORDIS Platform