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Acinar cell plasticity in the adult mouse pancreas (ACINPLAST)

Start date: Nov 1, 2007, End date: Oct 31, 2009,

"Cellular metaplasia may occur by transdifferentiation of one mature cell type into another, sometimes via an intermediate state of dedifferentiation. This type of cellular plasticity seems to be found in adult pancreatic acinar cells. The loss of differentiation may turn the acinar cells in facultative stem cells in the adult pancreas. Both in regeneration of exocrine as well as endocrine tissue ...
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