Search for European Projects

Over 40 European Projects Found

Searched on 125080 European Projects

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Polymeric ligands for molybdenum and rhenium clusters (PolyMoRe)

Start date: May 1, 2013, End date: Apr 30, 2015,

... fully exploit the terrific potential of MeCs, methods will be developed to incorporate them into organic polymers to create novel materials with a plethora of applications that include bioimaging, cancer treatment, LEDs and solar cells. These materials will provide alternatives to expensive and environmentally harmful materials currently in use. Thus PolyMoRe will contribute significantly to the ...
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Blood test for clinical therapy guidance of non-small cell lung cancer patients (LungCARD)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

Lung cancer is the most common cancer worldwide. NSCLC alone make up about 75% of all lung cancers and most hospitals currently test all NSCLC patients for EGFR mutations (pharmacogenomics) for treatment decision (personalised medicine) – i.e., patients with mutation(s) in EGFR gene should receive a EGFR-Tyrosine Kinase Inhibitor (TKI) drug (e.g. afitinib) treatment; while those that do not presen ...
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 8

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IN-OVO AUTOMATION FOR CANCER DRUG DISCOVERY (OVOMATIC)

Start date: Jan 1, 2017, End date: Jun 30, 2017,

...tion of 6-9 months. It represents a huge obstacle for the pharmaceutical industry, leading to fewer new drugs brought to market each year, and insufficient treatments for severe pathologies such as cancer or orphan diseases. INOVOTION can play a major role in solving this huge societal issue: we have the technology to revolutionize drug discovery by automating in vivo drug evaluation for efficacy ...
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Amélioration de l'efficaité et de la biodisponibilité des médicaments (Improving Drugs Efficacy and Availability) (IDEA)

Start date: May 31, 2009, End date: Jun 29, 2013,

...e regulatory authorities since 1995 have poor solubility, poor permeability, or both. The IDEA project aims at overcoming this major bottleneck. All types of diseases will be addressed, although, anticancer drugs exhibit particular challenges during formulation. Cancer is currently the second leading cause of death in Europe and the disease takes a very high human toll. This is particularly true f ...
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Enabled Media

Start date: Aug 1, 2015, End date: Feb 29, 2016,

... Health Organisation shows that around 15% of the world population are disabled, equating to over 1bn people. Disabled adults are 3 times more likely to have heart disease, stroke, diabetes, or cancer than non-disabled adults. They also often have to deal with secondary/ associated conditions (pain, fatigue, depression, weight gain, spasticity, seizures, balance and thermoregulatory problems) r ...
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Precision Therapies in Lung Squamous Cell Carcinoma (PrecTherLSCC)

Start date: Oct 1, 2016, End date: Sep 30, 2018,

Lung squamous cell carcinoma (LSCC) represents one third of lung tumours; 550,000 cases are diagnosed annually worldwide (20% occur in Europe). Treatment options for this cancer type are still scarce. Identification of LSCC genetic drivers is thus an essential unmet need for developing novel therapies for this disease.In a stepwise multidisciplinary approach, we will determine if TNIK (Traf-2 and ...
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Identification and characterisation of novel WWP2 substrates and their role in chondrogenesis and osteoarthritis (ChondUb)

Start date: Jul 1, 2016, End date: Jun 30, 2018,

...esis is only poorly understood. There is no cure available and current treatment involves pain relief and joint replacement surgery. WWP2 is an ubiquitin ligase involved in stem cell differentiation, cancer development and immune responses, and importantly plays crucial roles in chondrogenesis and craniofacial development. However, its role in cartilage biology and OA development has not been eluc ...
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Feasibility study on Opto-Magnetic Imaging Spectroscopy for cancer screening (OMIS)

Start date: Mar 1, 2016, End date: Aug 31, 2016,

Cancer is among the leading causes of death in the modern world with over 8 million cancer related deaths globally and over 1 million in the EU. The estimated economic costs of this EU social problem in 2009 was over €120 billion with the healthcare costs at 40% of this amount. Early identification of cancers continues as a key priority to reducing loss of life and subsequent treatment costs. Scr ...
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Identification of genes and pathways regulated by the HAT activity of MOZ (HAT-MOZ-sphere)

Start date: Sep 1, 2015, End date: Aug 31, 2017,

... wide range of new and transferable skills through a variety of multidisciplinary training programs. Relying on the knowledge and expertise of her supervisor and the exceptionally high calibre of the Cancer Research UK Manchester Institute, this project will enable Dr Anne Largeot to achieve her long-term objective of obtaining a leadership position in a competitive European Institute
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Improving physical dosimetry and developing biologically-relevant metrology for spot-scanned proton therapy beams (ProtonSpotScanMet)

Start date: Sep 4, 2014, End date: Mar 3, 2017,

...n Therapy Centre, and the return host will be University College London, who are currently building a spot scanning proton therapy clinic. Collaborators from IBA Particle Therapy, the UK Institute of Cancer Research and the UK National Physical Laboratory will also be involved.The applicant will be trained in proton therapy dosimetry research techniques, as well as receive clinical training in pro ...
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The use of genetic profiling to guide prostate cancer targeted screening and cancer care (BARCODE)

Start date: Oct 1, 2014, End date: Sep 30, 2019,

"Prostate cancer is the commonest solid cancer in men in the European Community. There is evidence for genetic predisposition to the development of prostate cancer and our group has found the largest number of such genetic variants described to date worldwide. The next challenge is to harness these discoveries to advance the clinical care of populations and prostate cancer patients to improve scre ...
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The interaction and clearance of senescent vascular cells by the innate immune system (ICSIS)

Start date: Jun 1, 2015, End date: May 31, 2017,

Cell senescence plays a paradoxical but important role in physiology; it protects organisms against cancer but also contributes to age-related loss of tissue function. Senescent cells accumulate during ageing, particularly at sites of age-related pathologies such as vascular tissue, contributing to fibrotic cardiovascular disease. Therefore, the aim of this research is to understand why senescent ...
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Understanding the functional role of Retinoic Acid Receptor Beta2 in the development of oral cancer (RARBETA2 IN OSCC)

Start date: Oct 15, 2013, End date: Oct 14, 2015,

The most common cancer in India is oral squamous cell carcinoma (OSCC), a tumour with poor survival whose incidence has also markedly increased in the UK over the past 30 years. There has been much interest in chemoprevention of OSCC, but large clinical trials of agents such as Vitamin A analogues (retinoids) have proved disappointing. One reason is that the function of retinoids in precancerous ...
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Global Alliance for Chronic Diseases (GACD)

Start date: Jan 1, 2013, End date: Mar 31, 2014,

...ica) to coordinate research activities addressing on a global scale the prevention and treatment of chronic, non-communicable diseases such as cardiovascular diseases, diabetes, respiratory diseases, cancer and mental health. The first coordinated research programme of the GACD focuses on hypertension prevention and control in Low and Middle Income Countries. The specific objectives of the forthco ...
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Irradiation of model biomolecular nano-systems (RAD-NANO-BIOMOL)

Start date: Feb 1, 2008, End date: Jan 31, 2011,

...um. This represents a major current research challenge for physicists, chemists, and biologists, with important applications in quantifying the effects of radiation exposure, in particular during cancer therapies. A mobile cluster source will be constructed at the Open University (UK) in order to carry out 2-photon ionization experiments which probe the effects of solvated water molecules upon th ...
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Magnetic Energy Conversion in Fine Nanoparticle Systems (MENCOFINAS)

Start date: Aug 1, 2011, End date: Jul 31, 2013,

...nment-friendly nanotechnologies or in biomedicine. Examples include the use of magnetic nanoparticles (MPs) in devices for magnetocaloric refrigeration or for heating in the hyperthermia treatment of cancer. Investing in these areas is imperative if the European Research Area and the European nanotechnologies industry it to gain a worldwide leadership. Essential are scientific developments and als ...
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The association between type 2 diabetes diagnosis and diabetes medications with risk of cancer (Diabetes and cancer)

Start date: Sep 1, 2011, End date: Aug 31, 2013,

Type 2 diabetes and cancer are two chronic diseases that negatively influence the survival of millions of people worldwide. Diabetes has been shown in meta-analyses to be associated with an increased risk of several cancers, but these associations are not yet documented as causal. The evidence for specific diabetes drugs affecting cancer risk is limited, because randomized clinical trials are not ...
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Breaking Tolerance - Combination of Virotherapy and Immunotherapy for Cancer Treatment (Viral&Immune Therapy)

Start date: Feb 1, 2011, End date: Jan 31, 2013,

... to escape host immune system. Here, we propose to use the chemotherapeutic agent cyclophosphamide to temporally deplete suppressor T cells and recruit new dentritic cell progenitors. Second, to kill cancer cells, we propose to systemically deliver the potent tumour-killing (oncolytic) adenovirus ICOVIR15, which replicates selectively in cancer cells with pRB pathway mutations. In order to favour ...
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Characterisation of PI3K isoform roles in pancreatic cancerogenesis (PaCa/PI3K)

Start date: Apr 1, 2011, End date: Mar 31, 2014,

...sited classification of PI3Ks.PI3K signalling is altered (constitutively active) and correlated with a poor pronostic in pancreatic adenocarcinoma. Pancreatic adenocarcinoma is one of the most lethal cancers and no chemotherapeutic treatment is currently available for this type of cancer. In this proposal, I will study the isoform-specific role of the signalling enzymes PI3Ks using new unique mous ...
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Molecular and cellular heterogeneity of tumour stem cells in human glioblastoma (tumourstemcells)

Start date: May 1, 2011, End date: Apr 30, 2013,

"Despite the emergence of new targeted therapies, there is still no curative treatment for many human cancers. Through the need for the best combination and solution, a new theory has suggested that cancer is as a stem cell-driven disease and a growing body of evidence has supported this hypothesis.In this context, the applicant proposes to investigate the biological function and complexity of the ...
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Combining epidemiology and radiobiology to assess cancer risks in the breast, lung, thyroid and digestive tract after exposures to ionizing radiation with total doses in the order of 100 mSv or below (EpiRadBio)

Start date: Apr 1, 2011, End date: Mar 31, 2015,

Recent epidemiological studies suggest that cancer risk after exposures with doses comparable to the dose limits for occupationally exposed workers may be larger than assumed by ICRP in the derivation of these limits. The value of cancer risk from such exposures and its dependence on tissue, radiation type and individual factors is largely unknown. The innovative approach proposed here combines ep ...
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Pulmonary Imaging Network (Π-NET)

Start date: Nov 1, 2010, End date: Oct 31, 2014,

...dies. The main research activity line aims at applying MRI based techniques for diagnosis (human and preclinical activities) and treatment (only preclinical) monitoring of lung diseases (COPD, lung cancer, cystic fibrosis, asthma), without excluding the possibilities that other imaging techniques (nuclear, CT and optical imaging) and molecular approaches (including molecular imaging and metabolomi ...
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New bioactive agents based on natural products (NABIO)

Start date: Jun 1, 2010, End date: May 31, 2012,

"More than 1 in 3 people in the EU will develop cancer during their lifetime. Despite huge investment, insufficient new bioactive molecules are emerging, and there is urgent need for a different approach to research in this area. Drawing inspiration from Nature, the Fellow will investigate natural products with anticancer potential. The objective of the IEF is to support the career development of ...
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Quantum chemical and combined quantum mechanical/molecular mechanical (QM/MM) modelling of oestrogen biosynthesis and metabolism (OestroMetab)

Start date: Oct 1, 2009, End date: Sep 29, 2012,

...nifold role in the correct functioning of the human body, which is especially pronounced in the case of women. Prolonged exposure to oestrogen has been shown to increase the risk of developing breast cancer due to the cumulative effect of toxic metabolites formed from oestrogens. State-of-the-art treatment of breast cancer involves inhibition of aromatase, the enzyme responsible for the last step ...
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Transgenic models of mammalian meiotic exit (Perry/mII/tg)

Start date: Apr 1, 2010, End date: Mar 31, 2014,

...xit in mammals. Ignorance about meiotic exit can and must be addressed; the mechanisms that underlie the period of meiotic exit impact all changes in cellular potency, including those predisposing to cancer and rationales for deriving induced pluripotent stem (iPS) cells and the emergent field of regenerative medicine in general. The present proposal addresses this gap in our understanding in mice ...
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 1

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Particle Training Network for European Radiotherapy (PARTNER)

Start date: Oct 1, 2008, End date: Sep 30, 2012,

...g field of hadron therapy. This is an interdisciplinary, multinational initiative, which has the primary goal of training researchers who will help to improve the overall efficiency of ion therapy in cancer treatment, and promote clinical, biological and technical developments at a pan-European level, for the benefit of all European inhabitants. This need has particular urgency since two particle ...
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Oral Off-patent Oncology Drugs for Kids (03K)

Start date: Sep 1, 2008, End date: Aug 31, 2011,

"There is an urgent need for appropriate oral formulations of anticancer drugs for the treatment of paediatric malignancies in children. The goal of the O3K consortium is to develop oral liquid formulations of Cyclophosphamide and Temozolomide, important chemotherapeutics which have been identified in the list of paediatric needs by EMEA (EMEA/197972/2007). Both off-patent drugs are widely used or ...
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 9

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Tumour Heterogeneity and Somatic Evolution of Unstable cancer genomes (THESEUS)

Start date: Jun 1, 2014, End date: May 31, 2019,

SummaryThe majority of metastastic solid tumours remain incurable. In-depth analysis of tumour genomes is revealing evidence for branched evolution and cancer subclonal spatial and temporal intratumour heterogeneity (ITH). Drivers of ITH such as chromosomal instability (CIN) are associated with drug resistance and poor clinical outcome. However, despite increasing knowledge of tumour diversity, th ...
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EUBET

Start date: Sep 1, 2016, End date: Aug 31, 2018,

Bromangymnasiet in Hudiksvall is situated in a region of very high unemployment, among the young it is the highest percentage in the country (25 %). Our school has the task and mission to develop an intercultural teaching practice supported by inclusive, innovative methods and entrepreneurship to achieve a more entrepreneurial learning for the benefits of our students. For some years now, we have ...
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iManageCancer - Empowering patients and strengthening self-management in cancer diseases (iManageCancer)

Start date: Feb 1, 2015, End date: Jul 31, 2018,

Chronic cancer treatment places new demands on patients and families to manage their own care. The iManageCancer project will support this challenge and provide a cancer disease self-management platform designed according to the specific needs of patient groups and focusing on the wellbeing of the cancer patient with special emphasis on psycho-emotional evaluation and self-motivated goals. The pla ...
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Design Principles of Microtubule Cytoskeleton Architectures during Cell Division (SPINDLEDESIGN)

Start date: Jul 1, 2013, End date: Jun 30, 2018,

The microtubule cytoskeleton provides an intracellular coordinate system and a mechanical scaffold for a multitude of essential cellular functions. The design principles underlying the dynamic organisation and function of the microtubule cytoskeleton are not understood. Using an in vitro reconstitution approach, we will determine the rules that govern which combination of mechano-chemical elements ...
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Vivre et travailler en Europe

Start date: Jun 1, 2016, End date: May 31, 2018,

Our goal is to provide students with additional foreign language skills in their professional field, but also open-mindedness and adaptability towards foreign countries in the perspective of living and working abroad.The 14 students concerned are in their junior year in a vocational high-school, and they will go abroad for 4 weeks (from May 29th to June 23th 2017).The teachers who are concerned a ...
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 11

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Targeting RAS oncogene addiction (RASTARGET)

Start date: May 1, 2013, End date: Apr 30, 2018,

Lung cancer is the most common type of malignant tumour worldwide and the leading cause of cancer-related death (335,000 deaths per year in Europe). The KRAS oncogene is frequently activated by point mutation in human lung cancer and mutations in the RAS family oncogenes are responsible for driving some 20% of all human malignancies. Most cell lines from RAS mutant tumours remain “oncogene addicte ...
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 2

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ATMINistrating ATM signalling: exploring the significance of ATM regulation by ATMIN (ATMINDDR)

Start date: Feb 1, 2012, End date: Jan 31, 2018,

ATM is the protein kinase that is mutated in the hereditary autosomal recessive disease ataxia telangiectasia (A-T). A-T patients display immune deficiencies, cancer predisposition and radiosensitivity. The molecular role of ATM is to respond to DNA damage by phosphorylating its substrates, thereby promoting repair of damage or arresting the cell cycle. Following the induction of double-strand bre ...
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 2

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QUantitative Imaging in Cancer: CONnecting CEllular Processes with Therapy (QUIC-CONCEPT)

Start date: Sep 1, 2011, End date: Dec 31, 2017,

...nt that the IBs are technically valid, that a measured change in the IB faithfully reflects the desired change in the underlying tumour pathology, and that the IBs can be readily deployed in multiple cancer centres in a robust, consistent, ethical, and cost-effective way acceptable to patients.2.(10% of resource, WP6) includes a portfolio of innovative approaches to devise, evaluate and introduce ...
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MAL: an actin-regulated SRF transcriptional coactivator (ACTINONSRF)

Start date: Oct 1, 2011, End date: Sep 30, 2017,

MAL: an actin-regulated SRF transcriptional coactivatorRecent years have seen a revitalised interest in the role of actin in nuclear processes, but the molecular mechanisms involved remain largely unexplored. We will elucidate the molecular basis for the actin-based control of the SRF transcriptional coactivator, MAL. SRF controls transcription through two families of coactivators, the actin-bindi ...
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 2

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The impact of chromosomal instability on health: Molecular causes and consequences of aneuploidy (PLOIDYNET)

Start date: Oct 1, 2013, End date: Sep 30, 2017,

Aneuploidy, an abnormal number of chromosomes, is a hallmark of cancer cells, affecting the majority of all human tumours. Aneuploidy arises when errors occur during mitosis, as the duplicated chromosomes are distributed between the two new daughter cells. Paradoxically, aneuploidy appears to have detrimental consequences for the physiology of untransformed cells in vitro, inhibiting rather than s ...
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Cross-species characterisation of CD8alpha+ dendritic cells and their role in immune regulation (DCSUBSET)

Start date: Sep 1, 2011, End date: Aug 31, 2017,

...8alpha+ DC equivalents in humans. The results from this proposal will illuminate the function of CD8alpha+ DC across species and open the door for using this intriguing DC subset in immunotherapy of cancer, infectious and autoimmune diseases.
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 2

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Investigating eukaryotic replisome dynamics at the single molecule level (SMI REP)

Start date: Aug 1, 2015, End date: Jul 31, 2017,

For cells to reproduce, an accurate duplicate of the genome must be created. This is no small task. The genetic information stored in each cell consists of ~6 billion pairs of nucleobases (base pairs, bp) assembled as a polymer 2 metres long and 2 nanometres in diameter, with the structural form of a double helix. For a mammalian cell to divide, this deoxyribonucleic acid (DNA) must be copied in a ...
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Vivre et travailler en Europe

Start date: Jun 1, 2015, End date: May 31, 2017,

Our goal is to provide students with additional foreign language skills in their professional field, but also open-mindedness and adaptability towards foreign countries in the perspective of living and working abroad. The 15 students concerned are in their junior year in a vocational high-school, and they will go abroad for 4 weeks (from May 29th to June 25th 2016). The teachers who are concerned ...
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