Search for European Projects

Over 40 European Projects Found

Searched on 125080 European Projects

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Molecular characterization and targeted elimination of metastatic pancreatic cancer stem cells (PA-CSC)

Start date: Jul 1, 2009, End date: Dec 31, 2014,

...er related deaths. Over the past decades, there has hardly been any substantial therapeutic progress regarding clinical endpoints. New hope has now been generated by the re-emerging cancer stem cell (CSC) concept. We have identified and characterized pancreatic CSC in the context of tumour growth, metastasis, and resistance to chemotherapy. To eventually be able to develop a targeted therapy for e ...
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Development of a more effective and safer therapeutic antibody for cancer treatment with a dual mechanism of action to eliminate CSCs and reactivate the tumour’s immune system. (CSC-IS)

Start date: Jul 1, 2015, End date: Dec 31, 2016,

...herefore urgent to develop more effective treatments against this fatal disease.There are two main reasons that explain the lack of success for the current treatments: In one hand, Cancer Stem cells (CSCs) are responsible from tumour initiation, maintenance, relapse and metastasis. On the other hand, the tumour has mechanisms to repress the patient’s immune system that attacks tumour cells. Our te ...
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Bidirectional interactions between cardiomyocytes and cardiac stem cells in the adaptive response to physiological stress (CSC PHYSTRESS)

Start date: Mar 1, 2008, End date: Feb 29, 2012,

...he treatment of many degenerative and life-threatening diseases has opened up a promising and exciting outlook for the future of medicine and drug therapy. The recent discovery of cardiac stem cells (CSCs) present in the adult mammalian heart, including the human, has stimulated a new and exciting field for cardiac biology. These resident cells express defined stem cell markers (i.e. c-kit), are c ...
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Intestinal stem cells and their role in colorectal cancer progression (CSC program)

Start date: Jun 1, 2010, End date: May 31, 2012,

...o isolate different tumor sub-populations in order to characterize them in detail. Interestingly, only a rare sub-population of tumor cells in CRC patients, so-called “cancer stem cells” (CSCs), is able to re-establish tumor growth in immune-deficient animals. We seek to understand how these tumor-promoting cells are genetically and functionally related to Lgr5+ ISC and Lgr5+ cells in CRC. Our res ...
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Targeting Cancer Stem Cells (CSC) for the development of more effective treatments to cure cancer patients (Anti-CSC)

Start date: Dec 1, 2012, End date: Nov 30, 2013,

...d EU, is 14 months and its 5-yr survival less than 5%. It is therefore urgent to develop more effective treatments against this fatal disease.It has been recently demonstrated that Cancer Stem Cells (CSCs) are responsible from tumour initiation, maintenance, relapse and treatment resistance, and therefore therapies targeting CSC should eradicate the tumour. Our team has discovered a molecular path ...
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CSC Europa

Start date: Aug 1, 2016, End date: Oct 31, 2017,

The project will take place in Santiago de Compostela during 10 months, from 1st of October 2016 to 31st of July 2017, across the cooperation of Germany, Austria, Croatia, Denmark, Turkey and Spain.Host organizations are cultural centers that the city of Santiago offers to citizens in different neighborhoods of Santiago de Compostela. All of them intended to provide different artistic, cultural an ...
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Professionalization of fitness careers

...on, certification and professionalization of fitness careers, integrating European standards and references with regard to competences, qualification levels, European sectoral frames for competences (CSC). This would give the opportunity to face one of the major European challenge: having a high-level of qualification professional frame, seeking for a better coherence between training/education of ...
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Higher education student and staff mobility project

Start date: Jun 1, 2014, End date: Sep 30, 2015,

...r training - 1 Student mobility for traineership - 1 Student mobility for studies - 1 Within Staff mobility for teaching, 2 of the 2 planned actions have been carried out: Doc. Ing. Hana Bartošová, CSc. - 22.9. -24.9. 2014 -- SK Bratisl06.- The aim of the stay was to provide a series of lectures in the hosting institution in the field of management, management methods and techniques. Another aim ...
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Transfer of a prevention and fight against discrimination in the employmentdans le champ de l'emploi et de la formation

... suggest to adapt and implement this methodology in different countries through transnational partners organizations: Italy (Scuola Centrale Formazione), Spain (Fondacion Trinijove), Belgium (AID and CSC) and Great Britain (HITC). All partners belong to the same network, the European Coordinating Committee, which includes structures that are acting in the field of social inclusion and employment. ...
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SLA-Ready: Making Cloud SLAs readily usable in the EU private sector (SLA-Ready)

Start date: Jan 1, 2015, End date: Dec 31, 2016,

...ion concepts can be problematic, with uncertainties as to what is regulated, who is responsible & which laws apply. Building on the work conducted by EC SIG SLA, Certification & Code of Conduct, ETSI CSC, CSA WGs, ECP Steering Board, NIST, Gartner, SLA-Ready, delivers a reference model for Cloud SLAs & a set of best-practices & services to support cloud customers in the use of cloud SLAs through t ...
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4FOLD Reduction of the International Transport of Empty Containers by Folding (4FOLD)

Start date: Oct 1, 2014, End date: Mar 31, 2015,

...ew jobs, and tackling the aforementioned environmental and mobility defies.Currently, the 4FOLD container of HCI is the first 40ft foldable container in the world that has received both the CSC and ISO certifications. This prototype is at TRL7 as it is being demonstrated in an operational environment in 3 small international pilot projects. In this project the technical feasibility of commercial p ...
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Combining sea and coastal planning in Europe (C-SCOPE)

Start date: Jun 30, 2008, End date: Jun 29, 2012,

The C-SCOPE partnership was created to achieve a seamless, integrated approach to land and sea planning and management. The purpose of the project is to provide the foundation for strong, vibrant and sustainable coastal economies, which are in harmony with the environment. Involving all maritime sectors in their endeavours, both partners are concerned with encouraging and promoting sustainable an ...
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Reducing social Exclusion through a creative approach to reADing

Start date: Sep 1, 2016, End date: Apr 30, 2018,

READ is a 20-month capacity building project dealing with youth, literacy and social inclusion and involving 5 partners: 3 from Europe (CSC Danilo Dolci – Italy, RIS Mansion Rakičan – Slovenia, Amadeus Association– Austria), 1 from Asia (JRP – India) and 1 from Africa (ITF from Kenya).The aim of the project is to promote reading to young people in an integrated manner. READ addresses the problem o ...
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360° - Building Strategies for Communication in Contemporary Dance

Start date: Sep 1, 2016, End date: Dec 31, 2017,

...ing an authentic narrative. Le Pacifique, Grenoble: Researching and identifying relevant audiences and stakeholders for your work and to adjusting language and communication strategies appropriately.CSC, Bassano Del Grappa: Informing and engaging the audience.K3, Hamburg: Mapping online communication channels and how to best use them.HIPP, Zagreb: Will contribute to the design of the first and thi ...
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Ready-to-use 3D Cell Cultures for early de-risking in drug development (3DCC)

Start date: Dec 1, 2016, End date: Apr 30, 2017,

...ge tissue culture facilities. This new solution is a ready-to-use 3D spheroid culture in standard 96 well plate format that allows customers to profile their pipeline of compounds for their effect on CSC populations using 3D culture models. Thanks to the 3DCC, a business opportunity appears to develop a multi-million euro business capitalizing on the thriving interest from Pharma in finding novel ...
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Tour du RhEin -

Start date: May 1, 2016, End date: Oct 31, 2016,

...rticipants how to disseminate the project : by films, photos or records. This testimony will be made throughout the project to be presented at the closing of our summer activities with our partner CSC Hautepierre in StrasbourgWe hope that this time of the French-german journey is the beginning of relations that persist beyond the project . The idea is to allow further meetings in 2016.
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Emotional Education for Early School Leaving Prevention

Start date: Sep 1, 2015, End date: Aug 31, 2018,

... risk of ESL and disadvantage This project is based on the partnership of 7 diverse organisations from 6 EU countries introducing new ideas in education: 1 private school (ASIST-DOGA), 4 NGOs (CSC, ETC + CILSDGC + VM), 1 Foundation (ROGERS) & 1 University (UOG) with extensive experience of working in schools and in the delivery of projects addressing school education, disadvantage, research & deve ...
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MEDART – Methods of Education for Disadvantaged Adults Rooted in Theatre

Start date: Sep 1, 2015, End date: Aug 31, 2017,

...isations. Divadlo bez domova, Teatr Grodzki, Društvo ProSoc, acta, AHA Theatre and Asociación Acunagua are experts in the field of drama therapeutical work with disadvantaged groups of people. CSC Danilo Dolci has a lot of expertise in the areas of non-formal and adult education and uses theatre as a tool for personal development. School of Social Work, which is a department in University of appli ...
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Tour du RhEin, climat et COP 21

Start date: Jul 20, 2015, End date: Oct 20, 2015,

... participants how to restore the project : by films, photos or records. This testimony will be made throughout the project to be presented at the closing of our summer activities with our partner CSC Hautepierre in Strasbourg We hope that this time of the French-german journey is the beginning of relations that persist beyond the project . The idea is to allow further meetings following the proje ...
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Higher education student and staff mobility project

Start date: Jun 1, 2015, End date: Sep 30, 2016,

... field of exchange of experience as well as the organisation of the daily agenda of the Study Department. Profiles of participants: Staff mobilities for teaching: doc. PhDr. Jana Marie Šafránková, CSc . expert in the field of management and human resources. Destination: Politechnika Warsawska (PL). The aims of the mobility were to present a series of lectures on the issue of human resources. Pa ...
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Europe in Crisis: Challenges and Scenarios for Cohesion

Start date: Sep 1, 2014, End date: Aug 31, 2015,

...ectives for European Cohesion which also includes the elaboration of concrete policy proposals. In a nutshell the project “Europe in Crisis: Challenges and Scenarios for Cohesion” (EU-CSC) foresees two major outputs and outcomes, which guide all other project activities: Firstly, we organize a multidisciplinary high-level conference which brings together international researchers, policy makers an ...
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Youth MEDIocracy Makers

Start date: Sep 1, 2014, End date: Aug 31, 2016,

Freedom of expression is essentially connected with the human rights and the concept of democracy. Especially, it is important for young people because it is essential to help them to build their consciousness and knowledge of the world and of current events. Young people need to discover new and different ways to communicate in order to develop themselves personally and socially. On one side, mor ...
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Emergence of Cognitive Grasping through Emulation, Introspection, and Surprise (GRASP)

Start date: Mar 1, 2008, End date: Feb 29, 2012,

Compared to humans or primates, the ability of contemporary robotic hands is suprisingly limited, they can grasp only few objects in constricted poses with limited grasping postures and position. The aim of GRASP is the design of a cognitive system capable of performing tasks in open-ended environments, dealing with uncertainty and novel situations. We have decided to study the problem of object m ...
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Identification of the genetic and/or epigenetic events that lead to mesenchymal transformation in glioblastoma (GAMNG)

Start date: Oct 1, 2010, End date: Jul 6, 2014,

...l gene signature. Overexpression of these two transcription factors reprograms neural stem cells along the aberrant mesenchymal lineage, whereas gene silencing in glioma cancer initiating cells (CSC) reduce tumor growth and aggressiveness. Recently, the Cancer Genome Atlas Network has provided information on genomic abnormalities that have allowed the expansion of previous glioblastoma classificat ...
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Pan-European Research infrastructure on High Performance Computing for 21st century Science (HPC-EUROPA2)

Start date: Jan 1, 2009, End date: Dec 31, 2012,

...rvice for almost two decades. The HPC-Europa2 partnership includes as Transnational Access centres CINECA (Italy), BSC (Spain), EPCC (UK), HLRS (Germany), SARA (The Netherlands), CINES ( France) and CSC (Finland). The project is organised around its core activity, the Transnational Access (TA) HPC service provision. Over the four year life span of the action, the TA will provide HPC services, sp ...
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Identification and Genetic Profile Characterization of Lgr5 positive Colon Cancer Stem Cells (ICSC Lgr5)

Start date: May 1, 2009, End date: Apr 30, 2011,

...at a small reservoir of self-sustaining cells is exclusively able to self-renew and generate the heterogeneous cell population that constitutes the bulk of the tumour. Importantly, Cancer Stem Cells (CSC) not only fuel tumour growth but also tumor metastases. In 2002, Lgr5 was identified as a gene expressed in colon cancer. Therefore, the main goal of this project is to identify colon Cancer Stem ...
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European Education Connectivity Solution (EECS)

Start date: Jun 1, 2009, End date: May 31, 2011,

"The EECS project brings together three European SMEs and three academic researchers in order to develop a prototype campus card management system that will serve the unique needs and requirements of European Higher Education Institutions. EECS will recommend standards for campus card systems to the ISO and will build the prototype to the recommended standards in order to facilitate interoperabil ...
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Integrated Chemical synthesis and Screening in patient Cells (ICSC)

Start date: Mar 1, 2009, End date: Aug 31, 2011,

"The ICSC project is a “Research for SMEs” focused research project that is to develop an integrated high throughput chemical synthesis and cell-based screening platform for the development of efficacious novel drug candidates without the need for chemical nor cell biological infrastructure. The technology will put early drug discovery in the hands of institutions that have a comprehensive knowled ...
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Planetary Entry Integrated Models (Phys4Entry)

Start date: May 1, 2010, End date: Apr 30, 2014,

One of the major technological challenges associated with the access to planetary surfaces is the entry of the space vehicle in the planetary atmospheres at superorbital speeds. The problem is the very large heat released to the vehicle surface by the surrounding gas either as convective heating or as radiation. Optimization of the thermal shield design can have a profound impact on the overall mi ...
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A study of TGF-beta effects on breast cancer stem cells (TGF-beta and BCSCs)

Start date: Jan 1, 2010, End date: Dec 31, 2011,

...y tumourigenic subpopulation of cancer cells has recently been identified in primary and metastastatic breast cancer. This minority of cells termed tumour-initiating cells or “cancer stem cells“ (CSC) has been shown in several solid tumours to bear stem cell features such as the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumour. Correlating wit ...
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Similarities and differences between neural stem cells and cancer stem cells (Cancer stem cells)

Start date: Jan 1, 2011, End date: Dec 31, 2012,

...key-players harbouring the ability to form new tumors after transplantation. Such tumor founding cells share multiple characteristics with stem cells, and thus, are often called “cancer stem cells (CSC)”. With this regards, most anticancer treatments fail to be curative because they focus on the large cell population, but not on CSC. This illustrates the need to develop more efficient therapies. H ...
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EUROCANCER STEMCELL TRAINING NETWORK (EuroCSCTraining)

Start date: Jan 1, 2011, End date: Dec 31, 2014,

The recent identification of tumor initiating (TIC) or cancer stem cells (CSC) has opened a new area of research for scientists interested in cancer. Understanding the biology of cancer stem cells has already unraveled pathways and potential targets. However, accumulating data has underscored the complexity of the CSC research area and prompts hence the need for well-structured networks to provid ...
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Three Dimensional Single Cell Analysis of the Cancer Stem Cell Inducing Epithelial-Mesenchymal Transition Signaling Networks in Breast Cancer by Mass Cytometry (Signaling 3D)

Start date: Mar 1, 2014, End date: Feb 28, 2019,

Tumor metastases, relapse, and resistance to therapy are the main causes of death in cancer patients. Cancer stem cells (CSCs) drive cancer growth, are likely responsible for cancer reoccurrence, and provide the potential to colonize a metastatic site. A cell plasticity process called epithelial-mesenchymal transition (EMT) generates CSCs from epithelial cancer cells and simultaneously equips thes ...
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Evaluation of metastatic and angiogenic potential of cancer stem-like cells in distinct mouse models for lung and liver metastasis (Metastasis)

Start date: Nov 1, 2011, End date: Mar 5, 2014,

...Cs). BMDCs have been shown to provide the premetastatic niches that promote the angiogenic process and create an environment permissive for tumor cell homing and colonization. The cancer stem cell (CSC) theory defines a subset of cancer cells with the exclusive ability to drive the growth and spread of a tumor. This research proposal is founded on the hypothesis that the CSC theory also applies ...
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HarmoniSed ENvironmental Sustainability in the European food and drink chain (SENSE)

Start date: Feb 1, 2012, End date: Jan 31, 2015,

...ors (KEPI); (ii)Harmonised methodology for environmental impact assessment; (iii)SENSE-tool for environmental data collection; (iv)EID and EID-Communication Platform; (v)Certification Scheme Concept (CSC) for sustainability; (vi)Roadmap for policy and governance implementation.SENSE consortium is formed by a multidisciplinary team involving 23 partners from 13 countries made up by a combination of ...
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Testing and validation of bispecific antibody combinations targeting treatment-resistant cancer stem cells using organoid-based screening tools: a new drug discovery paradigm (SUPPRESSTEM)

Start date: Jun 1, 2013, End date: Nov 30, 2016,

...d 608,000 (EU 148,000) died of the disease. While some new treatments have been advanced in CRC many have failed clinical testing; metastatic CRC is still largely incurable.In CRC, Cancer Stem Cells (CSC) are responsible for tumour progression and resistant to standard chemotherapies. The Wnt signal transduction cascade controls normal colon physiology but also CSC maintenance. Deregulation of Wnt ...
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Nano-technology enabled repositioning of Disulfiram as an anti-cancer stem cell agent (NANODISCAN)

Start date: Jun 5, 2014, End date: Jun 4, 2016,

Most cancers remain ‘incurable’ and life-thretening. Cancer stem cells (CSCs) are the source of chemo/radioresistance and responsible for cancer recurrence which suggests the urgent requirement of CSC-targeting drugs. Drug development is a slow (15 years/drug) and costly (US$1.5bn/drug) procedure with only 5-25% of new oncology drugs in clinical development actually reaching the market mainly due ...
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Honor as a cultural mindset: Effects on cognition, emotions, and behavior in children and adults (Honor as Mindset)

Start date: Sep 1, 2013, End date: Jan 30, 2017,

...nic accessibility of honor is most easily seen in Middle Eastern, North African and Latin cultures. Rather than focus on between-group comparisons, I propose to use the Culture as Situated Cognition (CSC) Model to study when and how honor matters. The CSC Model has previously been used successfully to demonstrate that features of the environment can subtly cue both individualistic and collectivist ...
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The importance of the epigenome in tumour development and recurrence (EpiBrain)

Start date: May 1, 2014, End date: Apr 30, 2018,

I aim to develop methods to reverse epigenetic anomalies in cancer stem cells (CSCs) to switch off the unlimited cell division and cancer growth and to understand the involvement of epigenetics in tumour development and recurrence. Epigenetic alterations are observed at the earliest stages of neoplasia within stem cells. Importantly, the alterations are reversible and can potentially be “treated”. ...
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Knowledge production, communication and negotiation for coastal governance under climate change (KnowHow)

Start date: Jan 1, 2014, End date: Dec 31, 2016,

... for Scientific and Industrial Research (CSIR); and three European Partners: the Faculty of Social Sciences and Humanities of Nova University of Lisbon (FCSH), Portugal; the Climate Service Centre (CSC) of the Helmholtz-Zentrum Geesthacht, Germany; Delft University of Technology (TUDelft), Netherlands; and University of Bergen, Norway (UiB).
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