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More than 50% of drugs currently on the market are either natural product inspired derivatives or natural products. Despite this remarkable feat, the pharmaceutical industry has partly abandoned this traditional method of drug discovery resulting in a decline of newly approved drugs. In this context, we propose the development of a novel Pd-catalyzed cascade reaction to gain highly efficient entry ...

Small natural molecules represent an irreplaceable tool in the search for new agents and new directions in medicinal chemistry. In the cancer treatment area, the 79.8% of the new chemical entities approved for drug use from 1981 to 2006 were registered as naturally derived or inspired. The organic synthesis of natural product analogs of varying degrees of structural complexity is a powerful way of ...