Fraunhofer ITEM


: May 2, 2016


Looking for Partnership
About Me

In Vitro Toxicology, different biological test systems (primary cell cultures of human and animal origin, immortal and transgenic cell lines, co-culture systems, precision-cut liver and lung slices), different in vitro exposure conditions (liquid or soluble test substances, particulate substances in suspensions, airborne test substances as gases, aerosols, and particles) in the patented culturing and exposure system PRIT-ALI. In vitro ADME, CYP450 Characterization, OECD Guideline studies, GLP certification

Genotoxicity: Comet-assays, Micronucleus-assays, Chromosomal abberation assay

Functional Assays: Cytotoxicity, Oxidative Stress, Apoptosis/Senescence, Inflammation, DNA-damage/repair, Cell Cycle Analysis, Particle uptake, Transport studies

Analysis of molecular mechanism of action: Gene expression analysis, Toxicity signature and pathway-specific analysis (real-time RTqPCR based arrays), Transcriptom-wide gene expression analysis (Affymetrix-Microarrays), Epigenetics

Keywords and matching areas:

 Environment
 Health Care
 Cosmetics
 Pharmaceuticals
 Chemicals
 Nanotechnology and Nanosciences
 Horizon2020

Ideas in Progress

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