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Systematic functional analysis of intracellular parasitism as a model of genomes conflict (SYSCO)
Start date: 01 Sep 2007, End date: 28 Feb 2011 PROJECT  FINISHED 

The research program is a multidisciplinary functional genomics approach to study fundamental biological processes relevant to human health and to develop bioinformatics tools in systems biology. It will decipher the complex regulatory networks that control basic cellular processes in the context of intracellular pathogen infection as a paradigm of host/pathogen genomes conflict.This project will model the innate immune response of macrophages from two species (humans and mice) to an intracellular pathogen: Leishmania parasite. This model is one of the most intensively investigated at the levels of parasite, host immune response and genetics, and allows testing and validating theoretical models in the light of already available and expected data. In a combined strategy of experimental and theoretical work, we will systematically capture data on different levels of cellular information using state-of-the-art multiparametric molecular technologies.
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