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SUpeR REsolution Adaptive LIght Sheet Microscopy for high resolution volumetric imaging in turbid specimen (SURE-ALISM)
Start date: 15 Sep 2014, End date: 14 Sep 2016 PROJECT  FINISHED 

"Rapid high contrast imaging in combination with low light exposure makes light sheet microscopy particularly attractive for studying the three-dimensional development of biological specimens. Currently however, the highest resolution of light sheet microscopy can only be achieved with relatively transparent samples. To study more advanced stages of development, of particular interest in brain imaging, scattering and aberrations pose a significant obstacle to achieve super-resolution or even diffraction limited resolution. Adaptive optics can correct aberrations in situ, yet inhomogeneities in the sample can severely restrict the usable field-of-view. Here we propose the use of structured illumination with variable periodicity to reclaim the resolution for a wide field-of-view. This Marie Curie Fellowship will thus enable super-resolution light sheet imaging deep within turbid biological tissue."
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