Sick or Sound (SoS) is a project of four high schools in Germany, Rumania, Poland and Spain and their students (14-16 years old). It is designed to bind together disciplines, perspectives, teachers and schools of different nations of the European Union. Starting point is the students’ profound experience of being sick and the vital interest in being healthy. Departing from the distinction of feeling ill and the presence of objective diseases, the project will make an issue both of what the students undergo suffering from sickness and becoming sound and of what they learn through the media e.g. about infectious diseases like Ebola. The project´s first objective is a new approach to teaching Sciences, Mathematics and English. It will foster general and transversal skills, namely to formulate own SoS topics or to find strategies for getting information or doing research. By the use of advanced teaching environments like workshops, innovative experimental settings like chemical release principles, web based communication, teaching tools like a wiki or content management systems and interdisciplinary project oriented learning, SoS is to improve high performance and at the same time to prevent poor achievement and early school leaving. This is to be attained by improving teaching skills and through the motivation that the students draw from working on themes with real life relevance and a comprehensive view on a subject of vital interest with a European and a global perspective. The participating schools will work together in coordinating teaching activities; cooperating common projects like on the proliferation of infectious diseases or transnational comparisons of hygienic measures or cultural bound concepts of sickness; and in complementing each other through propagating themes each of them is specialized in. Along with the items directly referring to performance, having a good and critical look on sickness and suffering or the comparison over cultural borders will strengthen both classes and schools, foster tolerance among students and teachers, enhance the identity of the participants as Europeans and promote a better understanding of the human condition under the threat of becoming ill. The sustainability of the project results will be guaranteed, on the one hand the documentation of our activities, enabling others to emulate what we have done, on the other hand web based presentations not only of the teaching activities but also of the results and of open projects like a wiki, that are to be used, worked on, increased and improved by others as a ongoing productive outcome of the SoS-project.