Self-Replication in Dynamic Combinatorial Libraries
(DynaRep)
Start date: Feb 1, 2011,
End date: Jan 31, 2013
PROJECT
FINISHED
The host group has recently made a remarkable discovery: the spontaneous emergence of self-replicating molecules from a complex mixture of continuously interconverting peptide-derived compounds (dynamic combinatorial libraries). This project builds on this discovery and aims to come to a complete understanding of the mechanism of replication. Based on this understanding new replicators will then be developed. In the final stage the process of replication will be studied inside bilayer vesicles. If successful this will be the first example of a fully synthetic system that combines three important elements found in living systems: metabolism, replication and compartmentalization. Success of the project is critically dependent on combining the expertise of the host on dynamic combinatorial chemistry with the expertise of the researcher on the permeation of peptides through bilayer membranes.
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Coordinator
RIJKSUNIVERSITEIT GRONINGEN
€ 169 035,20- H.D. Veldhuis
- Broerstraat 5 9712CP GRONINGEN (Netherlands)
Details
- 100% € 169 035,20
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FP7-PEOPLE
- Project on CORDIS Platform