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  Written by Matteo Satta EU funding has always helped cities support their innovation processes, particularly on digital transformation and environment, but the approach is now moving toward a new ambitious […]
- Mistakes that Cities Should Be Avoiding in EU Projects
  
  By Matteo Satta Nowadays, we are seeing an increasing trend of people requesting to lower taxes and, as a result, public budgets. This leads many cities to try to find […]
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  By Matteo Satta The commission has been heavily investing in pilot Smart City projects for a long time, but you may often have R&D or innovation projects pretending to have […]
- How to involve a city in your project? Here are a few tips.
  
  Article written by Matteo Satta (Smart) City projects are more and more funded by the European Commission, but consortia often struggle to get cities on board or really engage them. […]
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RNA-codified release of cytotoxic peptides from PNA prodrugs as a new therapeutic approach to cancer (MolecularDoctors)
Start date: Apr 1, 2011, End date: Mar 31, 2013 PROJECT FINISHED

In this proposal we intend to develop a new medicinal chemistry concept base on cell-personalized delivery of tailored drugs. Relying on basic chemical tools such as proximity-induced acyl transfer reactions and catalytic turnover- we will use RNA biomarkers of cancer cells to trigger the specific expression of cytotoxic drugs. This approach, in addition to contribute to basic science in chemistry and chemical and cell biology and suggest new therapeutic strategies, might allow to overcome the most important observed complications in cancer treatment: selectivity and resistance.

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Coordinator

HUMBOLDT-UNIVERSITAET ZU BERLIN

€ 163 242,40

Ulrich Winderl
UNTER DEN LINDEN 6 10099 BERLIN (Germany)

Details

100% € 163 242,40
FP7-PEOPLE
Project on CORDIS Platform

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RNA-codified release of cytotoxic peptides from PNA prodrugs as a new therapeutic approach to cancer (MolecularDoctors)
Start date: Apr 1, 2011, End date: Mar 31, 2013 PROJECT FINISHED