The issues faced today with biochemical sensors are device reliability and power consumption, liquid handling over extended periods of time, as the micro-dimensioned fluidic channels are prone to blockage, and micro pumps/valves being unreliable. The aim of this proposal is to develop a biocompatible molecular sensor that would address the key issues holding biocompatible sensors and would be at the forefront of molecular sensing. Advantages of such sensors would be selectivity for target ions in the body such as sodium, potassium and calcium. Sensors of this nature would be important in areas of every day life for example, monitoring cancer, / cancer pass surgery, obesity and people recovering from heart surgery. Such molecular sensors would contain hybrid materials consisting of monomeric components polymerized within biocompatible ionic liquids yielding various platforms for modification. Doping of the ionogel hybrid material with a selective ionophore will enable ion selectivity and hypothetically develop any chemical or biological sensor by introducing its corresponding selective ionophore. This type of material would render most optical sensing technologies on the market obsolete.