Pulsatile Viscous and Viscoelastic Microfluidics (MICROPULSATILE)
Pulsatile Viscous and Viscoelastic Microfluidics
Start date: Sep 3, 2012,
End date: Aug 13, 2015
The project aims at enhancing our theoretical understanding on how periodic forcing affects viscoelastic flow in one and two fluid phases at microscales and to apply such understanding to problems of biological and technological importance. The ‘state of the art’ regarding the understanding of the dynamics of one viscoelastic fluid phase at microscales, allow us to study fluids confined in complex geometries. For two fluid phases, more fundament research is needed since the effect of pulsed pressure gradients on the stability of interfaces is still to be explored in simple geometries. The project is therefore divided into two lines. Project line 1 tackles the problem of blood flow in tumor vasculature with the purpose of developing a methodology capable of predicting whether a tumor vascular network needs immediate attention or not by relating structure with hemodynamics. In particular we will study the effect of anastomosis, because it is most relevant around cancer tumors and its function has not been clearly established. Project line 2 concerns the study of the stability of interfaces in microfluidics forced by pulsed pressure gradients. We will develop fundamental knowledge to elucidate the role that play, on the interface instabilities, surface tension, confinement, dynamic wetting and degree of viscoelasticity. Results of this research are important from a scientific perspective and might lead to innumerable applications in microfluidic LAB-ON-A-CHIP devices.
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