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Preparing market introduction of DN-X-PRO - a breakthrough solution for real-time studies of DNA-protein interactions at single-molecule resolution (PREMADIX)
Start date: Dec 1, 2013, End date: Nov 30, 2014 PROJECT  FINISHED 

Through ERC-funded research, Prof. Wuite developed the DN-X-PRO as a method and instrument that enables direct visualization of DNA-protein interactions in real-time, at the single-molecule level, at super-resolution, under conditions similar to the cellular environment. Using the DN-X-PRO, researchers can manipulate and measure mechanical and structural properties of DNA-protein complexes, while simultaneously localizing individual proteins on the DNA, with nanometer accuracy and super-resolution. To date, such studies can only be performed by separate application of two or three different instruments, in conditions that do not resemble the cellular environment, with lower resolution. This results in a strong proposition to biomolecular researcher labs worldwide, allowing conduct of a range of experiments that are very complicated or not possible to date.The PREMADIX project will result in a clear valorization strategy — based on elemental business insights that permit estimation of commercial and financial feasibility and business modeling and planning. Besides, a sound intellectual property (IP) strategy will be defined. In parallel, the DN-X-PRO will be physically prepared for marketing, translating the current prototype into a robust and user-friendly design accompanied by product sheets, control and analysis software, and user manuals. Finally, the PREMADIX team will assemble a business team, and start discussions with potential strategic partners and financers. By doing so, at the end of PREMADIX, the team will have strong assets for market introduction.
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