Practical Organic Synthesis Inspired by Nature (POSIN)
Practical Organic Synthesis Inspired by Nature
Start date: Oct 1, 2014,
End date: Sep 30, 2018
"The aim of this research is to use nature as a source of inspiration and direction to improve and develop synthetic organicchemistry. Through targeted total syntheses I will investigate and learn about the highly sophisticated way nature utilizesdimerizations to rapidly generate molecular complexity. I will demonstrate the power of this biomimetic strategy bysynthesizing a wide variety of complex dimeric natural products including phenylethanoids, alkaloids, lignans, andcoumarins. The expected outcome will be uniquely efficient synthetic strategies that significantly surpass all previousapproaches and new synthetic methodology that will be of broad use in organic synthesis. More generally I will learn hownature uses relatively simple processes to rapidly generate molecular complexity in a highly selective manner."
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