Search for European Projects

Gating mechanism and pharmacological modulation of nicotinic acetylcholine receptors (nAChR PAM-to-gate)
Start date: Apr 1, 2015, End date: Mar 31, 2017 PROJECT  FINISHED 

Pentameric ligand-gated ion channels (pLGICs), including nicotinic acetylcholine, 5HT3, glycine, and GABAA receptors, are membrane proteins specialized in the communication between neurons. These neurotransmitter receptors are the target of general anaesthetics, anxiolytics, alcohols and nicotine. In particular, enhancing the activity of neuronal nicotinic receptors holds promises in the treatment of pathologies including nicotine addiction, schizophrenia and Alzheimer’s disease. The current project aims at deciphering the molecular and pharmacological determinants of positive allosteric modulators of neuronal nicotinic receptors. We will over-express and purify these proteins, study their pharmacology through electrophysiology in cell lines and planar lipid bilayer, and surface plasmon resonance binding studies. Our study will provide insights into the molecular mechanisms of allosteric regulation, paving the way for the rational design of allosteric modulators with therapeutic potential.
Up2Europe Ads
Ing. Iva Mládenková PhD

 Horizon Europe
 Innovation & Research

Freelance EU funding analyst and consultant - Focused primarily on EU Direct Management Programmes, in particular H2020, Eras ...

Angelo Napolitano

 Partnership Management
 Transnational cooperation

Seeking to stimulate and improve the participation of Italian private and public stakeholders to EU projects
ONECO

 Erasmus+
 International Project Management

ONECO is a consultancy of European programs in the field of education, culture, employment and local development. From 1997 until ...

Jose Ospina Development Consultant

 Eco-Innovation
 Energy Efficiency

I have worked for over 35 years in a professional capacity in as  project developer and manager in areas related to sustainable development an ...

Marketkaps

 Horizon Europe
 LIFE programme

Marketkaps Senior Consultants are former Entrepreneurs and also Experts & Auditors for the European Commission (Horizon Europe, Eureka) and Fre ...

Joanna Elwira Sychta

 Entrepreneurship and SMEs
 Project Management

Developing and managing the R&D applications of the European Union Funds especially Horizon 2020 SME Instrument, Marie Curie Research and other ...

Ana Maria Solis

 Erasmus+
 Horizon Europe

Expert - Project Development & EU Funding Consultant in participatory processes 

MY SUCCESSFUL EXPERIENCES IN COMMUNITY GRANTS

Nuno Vaz Silva - C Consulting

 Creative Industries
 INTERREG

Expertise in EU projects and policies – drafting project proposals, technical and administrative assistance, support to project implementatio ...

Coordinator

Details