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Development of a Novel Treatment for Clostridium Difficile (DNTCD)
Start date: Dec 1, 2011, End date: Nov 30, 2013 PROJECT  FINISHED 

"We wish to exploit the need for effective treatment for nosocomial diarrhoea especially that caused by Clostridium difficiledisease (CDD). Patients treated with broad spectrum antibiotics are at greatest risk of CDD diarrhoea and many of thoseaffected are hospitalised elderly patients with serious underlying illnesses. Antibiotics can cause disruption of the normalintestinal flora, an important part of the immune system, leading to an overgrowth of CDD. Currently, some 2350 patientssuffering from chronic CDD in a number of countries have been treated by faecal bacteriotherapy (FB), using samplescollected from donors. Although this procedure is reported, in a number of small studies, to be around 90% effective, it ishazardous, in that infection from the donor could be transmitted to the patient and it involves delivery of faecal samples intothe duodenum via a nasal probe.We propose to treat CDD using a modified FB to restore the patient’s original intestinal flora (employing samples collectedfrom the patients themselves prior to their treatment) We will produce novel enteric-coated capsules, containing processedfreeze dried colonic flora that can be swallowed by a patient to restore their intestinal flora and immunise them againstfurther infection by CDD. RFID tags will be employed to associate capsules with the relevant patient and assist with sampleinventory.3 SMEs in 3 EU states and 5 distinguished research providers along with 1 OTHER SME in the coordination role will collaborate to provide the necessary technology to the project. The coordinator has previously coordinated an EU proposal and acted as a participant in projects over severalFrameworks. The outcome will be a non-antibiotic medicament to treat and prevent CDD The consortium plan to patent theIPR from the project, exploit and disseminate the technology worldwide and carry out animal and hospital clinical studies.There are no gender issues related to the proposal but animal and human studies will require ethical approval."
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