Construction of Well- defined Ubiquitin Conjugates (UB)
Construction of Well- defined Ubiquitin Conjugates
Start date: Oct 15, 2008,
End date: Oct 14, 2011
"Ubiquitination and deubiquitination of proteins has emerged as an important biological regulatory process. For any investigational and therapeutical purposes, well-defined ubiquitin(-like) conjugates are of prime importance and to date, these have mainly been constructed by enzyme based strategies. However, besides the general potential problems of enzymatic transformations (e.g. yield, isolation, expression), the promiscuous nature of ubiquitination severely limits their general applicability. Despite this and the growing evidence that structural organization of ubiquitin chains is more complicated and important than anticipated, the development of synthetic strategies towards well-defined Ub(ls) has received little attention. This proposal will present synthetic strategies which I believe hold great potential as general approaches towards well-defined ubiquitin conjugates. Chemical approaches and resulting reagents are not only desired for their analytical value but will also assist future developments of targeted therapeutics."
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