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Chemo-Enzymatic Manufacturing Routes to High- Value compounds (ChemoEnz)
Start date: Jun 1, 2015, End date: May 31, 2017 PROJECT  FINISHED 

The aim of this project is to bring together subject matter experts from the academic and non-academic sectors to develop a platform of “green” chemoenzymatic methods for the production of high value active pharmaceutical ingredients – both those currently on the market, and those in development pipelines of the Pharma industry. The partners will exemplify the use of the platform through its application in the production of 4 drugs currently on the market – namely Duloxetine, Atomexetine, Ramosetron and Paricalcitol. In order to achieve this objective the proposal brings together 3 partners with complementary skills:Kelada Pharmachem: Phase transfer catalysis/organo catalysis/scale-up of chemical processesCerbios Pharma: Biocatalysis and fermentation methodologies for drug productionIC-CNR: Protein crystallography and enzymatic engineering

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