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  Written by Matteo Satta EU funding has always helped cities support their innovation processes, particularly on digital transformation and environment, but the approach is now moving toward a new ambitious […]
- Mistakes that Cities Should Be Avoiding in EU Projects
  
  By Matteo Satta Nowadays, we are seeing an increasing trend of people requesting to lower taxes and, as a result, public budgets. This leads many cities to try to find […]
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  By Matteo Satta The commission has been heavily investing in pilot Smart City projects for a long time, but you may often have R&D or innovation projects pretending to have […]
- How to involve a city in your project? Here are a few tips.
  
  Article written by Matteo Satta (Smart) City projects are more and more funded by the European Commission, but consortia often struggle to get cities on board or really engage them. […]
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Chagas' disease - Inhibitor discovery and optimization for Trypanosoma cruzi trans-sialidase (TRANSSIADRUG)
Start date: Apr 1, 2008, End date: Aug 31, 2009 PROJECT FINISHED

"This proposal focus on finding new potential lead compounds to inhibit the trans-sialidase of Trypanosoma cruzi, as a step towards finding a drug against Chagas’ disease. A new high through-put enzyme assay will be used to scan a large library of small molecules and in combination with in silico pharmacophoric modelling this is expected to provide new types of scaffolds as well as identifying important functionalities in the ligand. Based on the obtained information a set of ligands will be designed. These ligands will be synthesised and further evaluated through the enzyme assay, kinetic and thermodynamical studies as well as structural studies. In an iterative optimization, these tools will be combined to obtain future generations of inhibitory ligands."

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Chagas' disease - Inhibitor discovery and optimization for Trypanosoma cruzi trans-sialidase (TRANSSIADRUG)
Start date: Apr 1, 2008, End date: Aug 31, 2009 PROJECT FINISHED