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Bottom-up Resolution of Functional Enantiomers from Self-Organised Monolayers (RESOLVE)
Start date: 01 Sep 2008, End date: 31 Aug 2012 PROJECT  FINISHED 

The high throughput identification of resolution systems for industrially important chiral chemicals will be approached using the bottom-up hierarchichal assembly from self-organised chirally nanostructured surfaces and the “Dutch resolution” family method to isolation of enantiomers. Molecular modelling, surface science, supramolecular chemistry and the critically important resolving library design will be used in synergy to develop systems which separate enantiomers and which can be patterned and miniaturised. The preparation of chiral surfaces and the knowledge of chiral discrimination phenomena at the nanoscale will be exploited to use them to template the formation of diastereomers, which in turn will lead to the formation of crystals (whose composition will be determined) containing pure enantiomers. The project’s end goal is a rapid method for the identification of resolving systems for optically active compounds, and would constitute a leap forward for the area.
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