Bottom-up Resolution of Functional Enantiomers from Self-Organised Monolayers
(RESOLVE)
Start date: Sep 1, 2008,
End date: Aug 31, 2012
PROJECT
FINISHED
The high throughput identification of resolution systems for industrially important chiral chemicals will be approached using the bottom-up hierarchichal assembly from self-organised chirally nanostructured surfaces and the “Dutch resolution” family method to isolation of enantiomers. Molecular modelling, surface science, supramolecular chemistry and the critically important resolving library design will be used in synergy to develop systems which separate enantiomers and which can be patterned and miniaturised. The preparation of chiral surfaces and the knowledge of chiral discrimination phenomena at the nanoscale will be exploited to use them to template the formation of diastereomers, which in turn will lead to the formation of crystals (whose composition will be determined) containing pure enantiomers. The project’s end goal is a rapid method for the identification of resolving systems for optically active compounds, and would constitute a leap forward for the area.
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Coordinator
- Alberto Sereno Alvarez
- CALLE SERRANO 117 28006 MADRID (Spain)
5 Partners Participants
- Karin De Jager
- Kadijk 9723 GC Groningen (Netherlands)
- Colin Cooper
- Brownlow Hill, Foundation Building 765 L69 7ZX LIVERPOOL (United Kingdom)
- Maria Vereeken
- Oude Markt 13 3000 LEUVEN (Belgium)
- Dany Vince
- PLACE DU PARC 20 7000 MONS (Belgium)
- Albert Schenning
- GROENE LOPER 5 5612 AE EINDHOVEN (Netherlands)