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Biologically Active Organic Compounds Interacting with Adenine-binding Proteins (bioactivecpds)
Start date: Jan 1, 2010, End date: May 1, 2015 PROJECT  FINISHED 

Proposed are rational design and synthesis of novel patentable organic compounds that are envisioned to be active against various adenine-binding proteins, e.g. kinases. The structures contain heterocyclic cores relatively unknown in the literature and will mimic interations of purine-containing biological substrates (especially ATP) with proteins that are relevant in oncology. The compounds will be synthesized by modern methods of organic synthesis, namely by ring-closing olefin metathesis and will be profiled in biological assays that include diverse biological targets, especially those that are related to the treatment of cancer.

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