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Advanced Tests about New Toxins appeared in Atlantic Area (Atlantox)
Start date: Dec 31, 2008, End date: Dec 30, 2010 PROJECT  FINISHED 

The effects of climate change and global temperature rising are imminent, irreversible and they impact directly or indirectly on the marine environment and population. Marine ecosystems are under the effects produced by fluctuation in water temperature; this is responsible for the settlement of favorable ecological conditions for toxins reproduction. Although the Atlantic area coast is not probably the most affected by the negative influence of climate changes, with more pressing in warmer waters, its effects are already visible and worrying, requiring actions to ensure optimum levels of food safety for people of this coastal area and to minimize the further impact of its consequences in other sectors such as fisheries or tourism. Toxic episodes are a major public health problem whose impact is moved to areas such as tourism and a reduced consumption of seafood. Many local economies of this coast space are subjected to uncertainty to rely upon live resources that are experiencing intense natural variability. Referring to this, the priority is presented to tackle the appearing and multiplying of marine biotoxins, it is to determine and ensure an effective control system detecting them, a fast and reliable one. The current mode of reference in the European Union, the mouse bioassay, it is not sufficiently sensitive, shows a significant change, requires time, is vulnerable to interference and is unethical in terms of animal welfare. The main objective of this project is to support and accelerate the development and introduction of a proper and efficient method of fast alternative controlling based on antibodies and functional tests for biotoxins. Achievements: The ATLANTOX project focused on the detection of new toxins emerging along the European coasts of the Atlantic Ocean and which are not regulated in the EU: spirolide, palytoxins and tetrodotoxins. Its main objective was to support and accelerate the development and introduction of an alternative, proper and efficient fast control method for these biotoxins, based on antibodies and functional tests.This project has mapped the risk of spirolides, ciguatoxins, tetrodotoxins and palytoxins and their analogues, ostreocins, in the South of Europe. The results clearly showed that ciguatoxin is an emerging risk to certain large fish of the Barracuda group in the Atlantic South of Europe, and that spirolides are a chronic presence in any sample taken in molluscs in any location.The project has also clearly demostrated that tetrodotoxin is a presence in gasteropods in the Atlantic South of Europe, and that palytoxin and ostreocins are a growing problem linked to warm waters, and that have so far been detected in the Mediterranean South of Spain and in the Atlantic South of Portugal. Given the extreme potency and danger of these compounds, the project aimed to develop fast methods for the quick, easy and inexpensive detection of all three toxin types. Two different technological solutions were developed for tetrodotoxin and palytoxins, and one for ciguatoxins.The project has also provided valuable information about the pharmacodynamics of toxins and their toxicological profiles, as well as on how to use metodological resources of analyses, currently available regarding control in laboratories with regard to food safety, especially concerning what problems may arise from the use of mass spectrometry for marine toxin detection and how to avoid these problems.Overall, this project has provided the scientific community, food safety operators and legislators with valuable new information about the new presence of these toxins in Europe, and with tools to counteract their presence in the food chain. ATLANTOX thus contributed towards understanding the impact of emerging toxins on the Atlantic coast and developing monitoring and control strategies.
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  • 65%   1 195 651,18
  • 2007 - 2013 Atlantic Area
  • Project on KEEP Platform
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