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Defining the genetic basis of differential susceptibility to infectious diseases is of importance for understanding the evolution of human genetic diversity, for identifying critical molecular pathways in disease resistance, and for the design of novel intervention strategies such as more effective vaccines.I propose to sequence the entire coding regions of all human genes in large numbers of case ...
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The proposal's overall aim is to improve cervical cancer prevention programs for HIV–infected women in Africa, by evaluating the effectiveness and cost-effectiveness of alternative screening strategies, and by developing algorithms leading to earlier detection and management of cervical cancer in these high-risk populations.The proposal's hypotheses are that: i) the use of simplified point of care ...
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