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MicroRNAs (miRNAs) are RNAs of ~21-24 nucleotides with pivotal regulatory roles in various developmental and physiological pathways. They inhibit the translation of mRNAs and thus constitute a “tuning” system for controlling post-transcriptional expression. While the understanding of miRNAs function in bilaterians such as flies, nematodes and mammals is expanding rapidly, little is known about miR ...

"Genetic and mutant analyses in Drosophila and other standard model organisms have revealed hierarchical gene networks and identified some key regulatory genes acting in animal development. While surprising conservation exists on a broad scale between distant phyla, significant differences have also been detected. Systems biology approaches in the main model systems have now revealed more complex ...