Search for European Projects

Over 40 European Projects Found

Searched on 125080 European Projects

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Clinical proof of concept through a randomised phase II study: a combination of immunotherapy and stereotactic ablative radiotherapy as a curative treatment for limited metastatic lung cancer (IMMUNOSABR)

Start date: Jan 1, 2017, End date: Dec 31, 2022,

IMMUNOSABR is geared towards opening up a new paradigm in treating metastatic cancer by obtaining clinical proof of concept for a novel bi-modal curative treatment strategy. High precision stereotactic ablative radiotherapy (SABR) is combined with immunotherapy to form a powerful synergistic anti-tumour strategy. The approach relies on the direct cytotoxic effect of SABR, the abscopal effect of ra ...
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 17

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High Resolution Mapping of Fetal and Adult B Cell Fates During Ontogeny (FatemapB)

Start date: Oct 1, 2017, End date: Sep 30, 2022,

FateMapB aims to understand how the unique differentiation potential of fetal hematopoietic stem and progenitor cells (HSPCs) contribute to functionally distinct cell types of the adult immune system. While most immune cells are replenished by HSPCs through life, others emerge during a limited window in fetal life and sustain through self-renewal in situ. The lineage identity of fetal HSPCs, and t ...
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A Systems medicine approach to chronic inflammatory disease (SYSCID)

Start date: Jan 1, 2017, End date: Mar 31, 2022,

"The SYSCID consortium aims to develop a systems medicine approach for disease prediction in CID. We will focus on three major CID indications with distinct characteristics, yet a large overlap of their molecular risk map: inflammatory bowel disease, systemic lupus erythematodes and rheumatoid arthritis. We have joined 15 partners from major cohorts and initiatives in Europe (e.g.IHEC, ICGC, Twins ...
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 16

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Stable and High-Efficiency Perovskite Light-Emitting Diodes (SHINING)

Start date: Mar 1, 2017, End date: Feb 28, 2022,

Light-emitting diodes (LEDs), which emit light by a solid-state process called electroluminescence, are considered as the most promising energy-efficient technology for future lighting and display. It has been demonstrated that optimal use of LEDs could significantly reduce the world’s electricity use for lighting from 20% to 4%. However, current LED technologies typically rely on expensive high-v ...
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Single-Molecule And Structural Studies Of ATP-Dependent Chromatin Remodelling (ChromatinRemodelling)

Start date: Mar 1, 2017, End date: Feb 28, 2022,

The packaging of genetic information into chromatin regulates a wide range of vital processes that depend on direct access to the DNA template. Many chromatin-interacting complexes impact chromatin structure and their aberrant regulation or dysfunction has been implicated in various cancers and severe developmental disorders. A better understanding of the roles of chromatin-interacting complexes i ...
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Chemistry and Biology in Synergy - Studies of hydrogenases using a combination of synthetic chemistry and biological tools (CaBiS)

Start date: Feb 1, 2017, End date: Jan 31, 2022,

My proposal aims to take advantage of my ground-breaking finding that it is possible to mature, or activate, the [FeFe] hydrogenase enzyme (HydA) using synthetic mimics of its catalytic [2Fe] cofactor. (Berggren et al, Nature, 2013) We will now explore the chemistry and (bio-)technological potential of the enzyme using an interdisciplinary approach ranging from in vivo biochemical studies all the ...
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Towards middle-range theories of the co-evolutionary dynamics of multi-level social-ecological systems (MUSES)

Start date: Feb 1, 2017, End date: Jan 31, 2022,

Humans have the capacity to change the biosphere from local to global scales while at the same time fundamentally depending on a functioning biosphere for their well-being. Moreover human societies are increasingly affected by global change and adapting to it in multiple ways. These interdependencies give rise to non-linear, cross-scale dynamics that pose significant challenges for analysis and go ...
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Novel Approach to Systematically Characterize Exercise- and Nutrient- responsive genes in Type 2 diabetes and cardiovascular disease (NASCENT)

Start date: Feb 1, 2017, End date: Jan 31, 2022,

Proposal summaryType 2 diabetes and cardiovascular disease are devastating and costly morbidities whose prevalences are increasing rapidly around the world. As such, there is an urgent need to develop innovative and effective prevention and treatment strategies. As numerous clinical trials have shown, lifestyle modification is by far the best way to prevent these diseases, with lifestyle being twi ...
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Healthy minds from 0-100 years: Optimising the use of European brain imaging cohorts (Lifebrain)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

Our main objective is to identify determinants of brain, cognitive and mental health at different stages of life. By integration, harmonisation and enrichment of major European neuroimaging studies of age differences and changes, we will obtain an unparalleled database of fine-grained brain, cognitive and mental health measures of more than 6.000 individuals. Longitudinal brain imaging, genetic an ...
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 16

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European Human Biomonitoring Initiative (HBM4EU)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

The overarching goal of the European Human Biomonitoring Initiative (HBM4EU) is to generate knowledge to inform the safe management of chemicals and so protect human health. We will use human biomonitoring to understand human exposure to chemicals and resulting health impacts and will communicate with policy makers to ensure that our results are exploited in the design of new chemicals policies an ...
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 43

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Early-life stressors and LifeCycle health (LIFECYCLE)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

Early life is an important window of opportunity to improve health across the full lifecycle. European pregnancy and child cohort studies together offer an unique opportunity to identify a wide range of early life stressors linked with individual biological, developmental and health trajectory variations, and to the onset and evolution of non-communicable diseases. LIFECYCLE will establish the Eur ...
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Reaching the effects of gastric bypass on diabetes and obesity without surgery (BYPASSWITHOUTSURGERY)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

Gastric bypass surgery results in massive weight loss and diabetes remission. The effect is superior to intensive medical treatment, showing that there are mechanisms within the body that can cure diabetes and obesity. Revealing the nature of these mechanisms could lead to new, cost-efficient, similarly effective, non-invasive treatments of these conditions. The hypothesis is that hyper-secretion ...
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Neural circuits underlying complex brain function across animals - from conserved core concepts to specializations defining a species’ identity (BrainInBrain)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

The core function of all brains is to compute the current state of the world, compare it to the desired state of the world and select motor programs that drive behavior minimizing any mismatch. The circuits underlying these functions are the key to understand brains in general, but so far they are completely unknown. Three problems have hindered progress: 1) The animal’s desired state of the world ...
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Evaluating a Combination of Immune-based Therapies to Achieve a Functional Cure of HIV Infection (HIVACAR)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

The main goal of HIVACAR proposal is to change the current paradigm of HIV treatment by obtaining a functional cure for HIV (i.e., control of viral load to levels below the threshold of 50 copies/ml and maintenance of high CD4+ T-cell count after discontinuation of antiretroviral therapy) thanks to effectively targeting residual virus replication and viral reservoirs. In order to do so, the planne ...
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 16

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H.C. Ørsted Fellows Programme – co-funded by Marie Skłodowska Curie Actions (COFUNDfellowsDTU) (COFUNDfellowsDTU)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

With the H.C. Ørsted Fellows Programme – co-funded by Marie Skłodowska Curie Actions (COFUNDfellowsDTU) DTU will attract highly talented young researchers through incoming mobility from around the world. The Programme takes place at the Technical University of Denmark (DTU) which is a top ranked university with focus on all Engineering Sciences as well as Life Science and Biotechnology.The Program ...
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The Violence Early-Warning System: Building a Scientific Foundation for Conflict Forecasting (ViEWS)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

The challenges of preventing, mitigating, and adapting to large-scale political violence are daunting, particularly when violence escalates where it is not expected. Early-warning systems of sufficient quality and transparency do not exist, limiting the ability of the international community to effectively assist affected populations. We propose to develop, test, and iteratively improve a pilot Vi ...
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Fundamental and Applied Science on Molecular Redox-Catalysts of Energy Relevance in Metal-Organic Frameworks (MOFcat)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

Organometallic redox-catalysts of energy relevance, i.e. water and hydrogen oxidation, and proton and carbon dioxide reduction catalysts, will be incorporated into metal-organic frameworks (MOFs). Immobilization and spatial organization of the molecular catalysts will stabilize their molecular integrity and ensure longevity and recyclability of the resulting MOFcats. The organized environment prov ...
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An Integrated European ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century (EU-ToxRisk)

Start date: Jan 1, 2016, End date: Dec 31, 2021,

The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemi ...
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 43

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Parallel network-based biocomputation: technological baseline, scale-up and innovation ecosystem (Bio4Comp)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

Many technologically and societally important mathematical problems are intractable for conventional, serial computers. Therefore, a significant need exists for parallel-computing approaches that are capable to solve such problems within reasonable time frames. Recently, part of our consortium demonstrated proof-of-principle of a parallel-computation system in which a given combinatorial problem i ...
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GALAXY: Gut-and-liver axis in alcoholic liver fibrosis (GALAXY)

Start date: Jan 1, 2016, End date: Dec 31, 2021,

Alcohol overuse is an important societal challenge with annual healthcare costs of over €22 billion in Europe. Alcohol is the main cause of liver cirrhosis, which is the 5th and 7th most common cause of life years lost in respectively Eastern and Western Europe. Cirrhosis is considered irreversible but its precursor, liver fibrosis, is reversible when detected before disease progression. GALAXY pr ...
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Mechanism of DNA-protein cross-link repair in S phase (DPC_REPAIR)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

DNA-protein cross-links (DPCs) are common DNA lesions caused by endogenous, environmental, and chemotherapeutic agents. Cells are susceptible to these lesions during S phase, as DPCs impede replication fork progression and are likely to induce genomic instability, a cause of cancer and aging. Despite its relevance to human health, the repair of DPCs is poorly understood. Research on DPC repair has ...
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Dis-inhibitory circuits in the human cerebral cortex (INHIBITHUMAN)

Start date: Dec 1, 2016, End date: Nov 30, 2021,

Temporal co-ordination of the activity of cortical neurons underlies cognitive processes. Intracortical inhibitory circuits set temporal windows for modulation of glutamatergic pyramidal cell firing. In non-human mammals, the activity of the GABAergic neurons is governed by other specialised GABAergic neurons, which can dis-inhibit pyramidal cells. The overarching aim of this project is to define ...
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The makeup of the modern horse: a history of the biological changes introduced by human management (PEGASUS)

Start date: Dec 1, 2016, End date: Nov 30, 2021,

The horse provided us with rapid transportation, an almost unrivaled secondary product that tremendously impacted the politico-economical trajectory of our societies, revolutionizing the circulation of ideas, people, languages, religions and communication. Horse chariotry and cavalry also changed warfare and beyond the battlefield new equestrian technologies have stimulated agricultural productivi ...
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 2

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Pathways to Alzheimer's disease (PATHAD)

Start date: Dec 1, 2016, End date: Nov 30, 2021,

Critical to our understanding of Alzheimer’s disease (AD) and also to finding therapies is determining how key pathological factors interact and relate to neuronal toxicity, symptoms and disease progression. My research has focussed on amyloid beta (Aβ) moities and demonstrated that cerebrospinal fluid (CSF) Aβ42 correlates with cerebral Aβ pathology; that Aβ accumulates in the brain 10-20 years p ...
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Integrated Arctic observation system (INTAROS)

Start date: Dec 1, 2016, End date: Nov 30, 2021,

The overall objective of INTAROS is to develop an integrated Arctic Observation System (iAOS) by extending, improving and unifying existing systems in the different regions of the Arctic. INTAROS will have a strong multidisciplinary focus, with tools for integration of data from atmosphere, ocean, cryosphere and terrestrial sciences, provided by institutions in Europe, North America and Asia. Sate ...
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 41

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Coordination of European Transnational Research in Organic Food and Farming Systems Cofund (CORE Organic Cofund)

Start date: Dec 1, 2016, End date: Nov 30, 2021,

Organic agriculture is considered to be one of the important development pathways towards a more sustainable agriculture and food production. This development has been and will be dependent on continuous research and innovation.CORE Organic started in 2004 and has been evolving for more than a decade. The present proposal for a CORE Organic Cofund will continue, to update and consolidate the serie ...
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Maintaining the Human Mitochondrial Genome (DELMIT)

Start date: Nov 1, 2016, End date: Oct 31, 2021,

Mitochondria are required to convert food into usable energy forms and every cell contains thousands of them. Unlike most other cellular compartments, mitochondria have their own genomes (mtDNA) that encode for 13 of the about 90 proteins present in the respiratory chain. All proteins necessary for mtDNA replication, as well as transcription and translation of mtDNA-encoded genes, are encoded in t ...
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Cryosphere-Carbon on Top of the Earth (CC-Top):Decreasing Uncertainties of Thawing Permafrost and Collapsing Methane Hydrates in the Arctic (CC-TOP)

Start date: Nov 1, 2016, End date: Oct 31, 2021,

The enormous quantities of frozen carbon in the Arctic, held in shallow soils and sediments, act as “capacitors” of the global carbon system. Thawing permafrost (PF) and collapsing methane hydrates are top candidates to cause a net transfer of carbon from land/ocean to the atmosphere this century, yet uncertainties abound. Our program targets the East Siberian Arctic Ocean (ESAO), the World’s larg ...
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 1

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Rotterdam, Umea and Glasgow: Generating Exemplar Districts In Sustainable Energy Deployment (Ruggedised)

Start date: Nov 1, 2016, End date: Oct 31, 2021,

The RUGGEDISED project will create urban spaces powered by secure, affordable and clean energy, smart electro-mobility, smart tools and services. The overall aims are:1. Improving the quality of life of the citizens, by offering the citizens a clean, safe, attractive, inclusive and affordable living environment.2. Reducing the environmental impacts of activities, by achieving a significant reducti ...
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Social and Political Economics: Theory and Evidence (ECOSOCPOL)

Start date: Nov 1, 2016, End date: Oct 31, 2021,

In this project, I will study how individual and social motives interact to drive individual decisions, a question that has fallen between the cracks of different social-science approaches. I will use a common theoretical framework to approach an important, but badly understood, general question: do social motives reinforce or weaken the effect of changes in individual motives? By modifying this c ...
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Joint European Master Programme on Advanced Materials Science and Engineering

Start date: Sep 1, 2016, End date: Sep 30, 2021,

... offered since 2005 by: Universität des Saarlandes (Saarbrücken - Germany); Université de Lorraine (Nancy - France), Universitat Politecnica de Catalunya (Barcelona - Spain) and Luleå Tekniska Universitet (Luleå - Sweden).• The consortium has a long experience following 25 years of collaboration within the EEIGM - École Européenned'Ingénieurs en Génie des Matériaux and several EU-Projects, includ ...
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 4

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Erasmus Mundus Joint Master Degree in Food Innovation & Product Design

Start date: Sep 30, 2016, End date: Sep 30, 2021,

The EMJMD FIPDes is a 2-year programme in Food Innovation & Product Design. It is the first course created to tackle the global challenges of food innovation along with product design and packaging. FIPDes trains a new generation of food professionals capable of working across borders, with an inclusive vision of innovation to create sound, sustainable and healthy food solutions for the future gen ...
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Novel niches for anaerobic methane oxidation and their biogeochemical sigificance (NOVAMOX)

Start date: Oct 1, 2016, End date: Sep 30, 2021,

Motivated by a series of recent discoveries, NOVAMOX provides the first comprehensive biogeochemical and microbial ecological analysis of methane consumption in anoxic freshwater systems and oceanic oxygen minimum zones, environments where such processes to date were largely ignored. I propose that anaerobic microbial methane oxidation pathways are important sinks in for methane in these environme ...
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 1

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From Fermi to Planck : a bottom up approach (NuBSM)

Start date: Oct 1, 2016, End date: Sep 30, 2021,

The Standard Model of particle physics is a hugely successful theory that has been tested in experiments at ever increasing energies, culminating in the recent discovery of the Higgs boson. Nevertheless, some major riddles cannot be addressed by the Standard Model, such as neutrino oscillations, the existence of Dark Matter, the absence of antimatter in the Universe. New fundamental principles, in ...
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 3

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Erasmus Mundus Masters in Journalism, Media and Globalisation

Start date: Sep 1, 2016, End date: Aug 31, 2021,

Mundus Journalism aims to develop and integrate innovative research and industry links into an established (2005) Erasmus Mundus Joint Masters’ degree in Journalism, Media and Globalisation, which is jointly delivered by five European and three non-European universities in close cooperation with media partners. The ambition of the two-year, 120-ECTS programme is to: (a) Reflect the contemporary i ...
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Contexts, networks and participation: The social logic of political engagement (CONPOL)

Start date: Sep 1, 2016, End date: Aug 31, 2021,

The statement that individuals’ immediate social circumstances influence how they think and act in the political sphere is a truism. However, both theoretical and empirical considerations have often prevented political scientists from incorporating this logic into analyses of political behavior. In the CONPOL project we argue that it is necessary to return to the idea that politics follows a socia ...
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Matrix during cancer progression (MATRICAN)

Start date: Sep 1, 2016, End date: Aug 31, 2021,

The extracellular matrix (ECM) is known to play a critical role in driving cancer progression, and yet we lack knowledge of its composition and structure. The goal of my ERC project is to investigate how alterations in biochemical composition and structural properties of the ECM during cancer progression impact on cell behaviour to drive metastasis, which is responsible for over 90% of cancer pati ...
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Northern Europe's timber resource - chronology, origin and exploitation (TIMBER)

Start date: Sep 1, 2016, End date: Aug 31, 2021,

Empirical evidence for the history of the exploitation of the timber resource in Northern Europe is stored in the material record. Archaeological finds, art-historical objects and built heritage have provided us with an extensive dataset of precisely dated wood from heritage contexts. This material is the key to details about the usage, condition and availability of the timber resource and details ...
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Biocompatible and Interactive Artificial Micro- and Nanoswimmers and Their Applications (ComplexSwimmers)

Start date: Sep 1, 2016, End date: Aug 31, 2021,

Microswimmers, i.e., biological and artificial microscopic objects capable of self-propulsion, have been attracting a growing interest from the biological and physical communities. From the fundamental side, their study can shed light on the far-from-equilibrium physics underlying the adaptive and collective behavior of biological entities such as chemotactic bacteria and eukaryotic cells. From th ...
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Breaking the paradigm: A new approach to understanding and controlling combustion instabilities (TAIAC)

Start date: Sep 1, 2016, End date: Aug 31, 2021,

It is well known that current and future low-emission combustion concepts for gas turbines are prone to thermoacoustic instabilities. These give rise to large pressure fluctuations that can drastically reduce the operable range and threaten the structural integrity of stationary gas turbines and aero engines. In the last 6 years the development of laboratory-scale annular combustors and high-perfo ...
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