Search for European Projects

Over 40 European Projects Found

Searched on 125080 European Projects

 ONGOING 
Traumatic Brain Injury (TBI) is a major cause of death and disability, leading to great personal suffering to victim and relatives, as well as huge direct and indirect costs to society. Strong ethical, medical, social and health economic reasons therefore exist for improving treatment. The CENTER-TBI project will collect a prospective, contemporary, highly granular, observational dataset of 5400 p ...
Read Project

 44

 FINISHED 
Conduct Disorder (CD) and Oppositional Defiant Disorder with symptoms of Conduct Disorder (which is included among the abbreviation “CD” throughout the proposal) has a highly negative impact for the affected individual as well as for families and society. Although the number of females exhibiting serious aggressive behaviours is growing, the majority of studies on aetiology and treatment of CD hav ...
Read Project

 19

 FINISHED 
The ageing of the European population represents a rapidly rising social and economic challenge. Especially cardiovascular morbidity increases with age, but unfortunately, elderly patients are often difficult to diagnose due to confounding factors, leading to uncertainties in clinical decision making with huge impact on patients’ outcomes. Hence, there is an unmet need for novel biomarkers for mor ...
Read Project

 22

 FINISHED 

Immunostimulatory Agonist antibodies for Cancer Therapy (IACT)

Start date: Nov 1, 2013, End date: Oct 31, 2017,

"This concerted action aims at providing new treatment options for cancer patients through boosting innovative drug development by European academia and industry. A wealth of preclinical data shows that the therapeutic impact of cytotoxic regimens is enhanced by simultaneous application of drugs that strengthen the immune system. The recent FDA-approval of Ipilimumab demonstrated that cancer immun ...
Read Project

 11

 FINISHED 
Neuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain, and non-coding RNAs (ncRNAs) regulate both immune and neuronal processes. Therefore, ncRNAPain proposes that ncRNAs are critically important master switches for chronic pain.ncRNAPain represents a multidisciplinary consortium of clinical partners, molecular and systems-level n ...
Read Project

 12

 FINISHED 
EURenOmics will integrate several established consortia devoted to rare kidney diseases with eminent need and potential for diagnostic and therapeutic progress (i.e. steroid resistant nephrotic syndrome, membranous nephropathy, tubulopathies, complement disorders such a haemolytic uraemic syndrome, and congenital kidney malformations). The Consortium has access to the largest clinical cohorts asse ...
Read Project

 29

 FINISHED 
Antimicrobial resistance is arguably the most significant challenge facing the EU health care system. The unnecessary use of antibiotics is a key driver in the development of antibiotic resistance. Cystic Fibrosis (CF) represents a unique disease model to study bacterial resistance and to explore therapeutic strategies for same, as chronic lung infection overlaps with acute lung exacerbations caus ...
Read Project

 15

 FINISHED 
The 4 SME Participants in the INTELLIPOOL project – ULTRAAQUA, VES, Electrocell and Swan aim to develop technology solutions to eliminate the severe adverse health effects caused by chlorinated disinfection by-products (DBP) in recreational bathing water facilities and simultaneously save energy, chemicals and water associated with pool water sanitation. We will create a toolbox of analytical/desi ...
Read Project

 10

 FINISHED 

Receptor signalling mediating malaria parasite motility (ParaMotSig)

Start date: Apr 1, 2012, End date: Mar 31, 2017,

Plasmodium sporozoites are the motile forms of the malaria parasite injected into the host by a mosquito. Sporozoite motility is essential for tissue penetration as well as host cell invasion and thus pathogenesis suggesting that blocking motility could potentially add a new way in controlling malaria. It is dependent on a parasite specific myosin, a highly divergent actin and plasma membrane prot ...
Read Project

 1

 FINISHED 
The overall concept of this research project is to assemble a consortium of international experts working together to develop new and innovative tools to be applied to the control of dengue in a global context. The core of the application focuses on parallel strategies aimed at:• improving diagnosis and clinical management of dengue through two linked work packages designed a) to identify readily ...
Read Project

 18

 FINISHED 
The consortium led by UKER and EuroHYP, the European Stroke Research Network for Hypothermia, proposes a large, multicentre clinical trial which will assess mild hypothermia as a novel treatment for ischemic stroke.Stroke is the second cause of death world-wide and the second cause of lost disability-adjusted life years in high-income countries. Stroke incidence rises exponentially with age, so it ...
Read Project

 38

 FINISHED 
Cardiovascular diseases remain the primary cause of morbidity and mortality in the western countries. Pharmacological treatment improves survival and quality of life, but does not reverse disease progression. Gene therapy could fill this void, owing to its ability to treat the underlying cause. Adeno-associated viruses (AAV) emanated in the past decade as potent vectors, owing to their tropism for ...
Read Project

 1

 FINISHED 
OPTiMiSE (OPtimization of Treatment and Management of Schizophrenia in Europe) will focus on two goals: optimising current treatments in Schizophrenia and explore novel therapeutic options for schizophrenia. The project intends to both address basic, but so far unanswered, questions in the treatment of schizophrenia and develop new and experimental interventions. It is expected that the project wi ...
Read Project

 25

 FINISHED 

The MEtabolic Road to DIAstolic Heart Failure (MEDIA)

Start date: Jan 1, 2011, End date: Jun 30, 2016,

More than 50% of heart failure (HF) patients present without a major deficit of left ventricular (LV) systolic function and are presumed to suffer from diastolic HF (DHF) because diastolic LV distensibility is usually impaired in these patients. The vast majority (~80%) of DHF patients is exposed to metabolic risk factors. The MEDIA consortium therefore investigates:1) how metabolic derangements c ...
Read Project

 23

 FINISHED 
The MDGs succeeded in generating consensus on and mobilising resources towards agreed goals. They were less successful at clarifying responsibilities for achieving them. The MDG target on sharing global health innovation is particularly ambiguous about the allocation of responsibilities.The members of the consortium behind this proposal assume that the new goals for global health will need to be b ...
Read Project

 14

 FINISHED 

European Training and Research in Peritoneal Dialysis (EUTRIPD)

Start date: Dec 1, 2011, End date: Nov 30, 2015,

Peritoneal dialysis (PD) and haemodialysis (HD) are life-saving renal replacement therapies for more than 200,000 patients with chronic kidney disease in Europe, and this number increases annually. Although PD and HD have similar mortality rates, PD offers major advantages in terms of quality of life, costs, home-based treatment opportunities and early patient survival. Moreover, PD, rather than H ...
Read Project

 13

 FINISHED 
Human papillomavirus (HPV) is responsible for approximately 25% of head and neck cancer (HNC) worldwide and appears to be associated with a better response to treatment and improved prognosis. Evidence suggests that HPV-induced HNC has steadily increased in the USA and some European countries in the last decades. However, whether this is a worldwide phenomenon and specific risk factors are associa ...
Read Project

 11

 FINISHED 
Multiple Myeloma (MM) is a currently incurable rare malignant plasma cell disease, which invariably relapses despite therapy. The objective of OVER-MYR is to understand the causes of drug resistance and relapse, develop novel strategies to overcome these, provide proof of principal for phase I/II trial, and thus impact on MM-patient’s survival.Currently-used drugs target both MM cells (MMC) and c ...
Read Project

 11

 FINISHED 

New Algorithms for Host Pathogen Systems Biology (SYSPATHO)

Start date: Oct 1, 2010, End date: Mar 31, 2015,

SYSPATHO focuses on the development of novel and generally applicable mathematical methods and algorithms for systems biology. These methods and algorithms will be applied to study the complex interactions of hepatitis C virus (HCV), a human-pathogenic virus of high medical relevance, with its host at the systems level. Using a multidisciplinary, integrative approach, PATHOSYS will (a) develop met ...
Read Project

 11

 FINISHED 
Major objective: It is our aim to develop a lipid based diet that is able to delay or prevent onset of Alzheimer’s disease and related diseases and has a stabilizing effect on cognitive performance in aging. Multiple lines of evidence suggest that there is a large overlap between risk factor of these three diseases. Importantly, there is equally strong evidence that prevention and treatment of the ...
Read Project

 19

 FINISHED 
RNA virus infections kill millions of humans annually, largely due to the lack of suitable vaccines and drugs to control them. This problem is addressed in this FP7 call and in response a consortium of Europe’s and Asia’s leading molecular virologists, structural biologists, medicinal chemists and bioinformaticians has been brought together to generate a state-of-the-art drug discovery and design ...
Read Project

 25

 FINISHED 
SaveMe project will address current urgent needs for pancreatic cancer diagnosis and treatment by exploiting partners’ expertise and most recent research achievements for the design and development of novel modular nanosystems platform integrating new functionalized nano-core particles and active agents. The modular platform will enable the design of diverse active nanosystems per diagnostic or th ...
Read Project

 23

 FINISHED 

Tailored implementation for chronic diseases (TICD)

Start date: Feb 1, 2011, End date: Feb 28, 2015,

Project aim. Chronic diseases represent an important challenge facing healthcare systems. Research has consistently shown gaps between knowledge and practice for chronic illness care. Tailoring implementation interventions implies that the choice and content of implementation interventions are based on assessment of local barriers and enabling factors. It is widely believed that tailoring contribu ...
Read Project

 7

 FINISHED 
Virus infections remain a major cause of disease, with dramatic costs in mortality, morbidity, and economic loss worldwide. There is an unmet need for potent antiviral drugs, in particular against viruses with a (+)RNA genome which include many important pathogens of humans and animals.Antiviral drug development requires a detailed understanding of virus replication and effective translation of th ...
Read Project

 12

 FINISHED 
The vision on a future high-precision radiation therapy utilizing either particle or photon beams is a treatment on a technological level which allows for: (1) obtaining information on relevant tumour parameters (volume, position, topology, density - also of the surrounding tissue) during every moment of therapeutic irradiation; (2) adapting the treatment plan in real time; and (3) initiating the ...
Read Project

 12

 FINISHED 
Background A crucial goal of infectious disease surveillance is the early detection of epidemics, which is essential for disease control. In China, the current surveillance system is based on confirmed case reports and only covers notifiable diseases. In rural China, it is not practical for health units to perform laboratory tests to confirm disease and people are more likely to get 'old' and emer ...
Read Project

 5

 FINISHED 
54 partners from 34 institutes have formed an EC-funded Network of Excellence (NoE) in basic malaria research, the European Virtual Institute for Malaria Research (EVIMalaR). Over the previous >5 years as the NoE Biomalpar these partners successfully broke down many barriers to cooperation pursuing a programme of integrated research. This was greatly assisted by the Biomalpar PhD School whose stud ...
Read Project

 14

 FINISHED 
Recent studies have indicated that combinatorial treatments that target multiple mechanisms are necessary to address the limited regenerative capacity in the adult nervous system. We have shown that chemotropic guidance by growth factor gradients, activation of cell-intrinsic regenerative programs and suitable cellular bridges at a lesion site allow for axons to extend across a lesion site in the ...
Read Project

 1

 FINISHED 

European NoVel Imaging Systems for ION therapy (ENVISION)

Start date: Feb 1, 2010, End date: Jul 31, 2014,

Following the pioneering experiences which lasted several decades, particle therapy has become a recognized way of curing cancer. 2 new European dual-ion facilities (Heidelberg, Pavia) will soon become operational, followed by several others which are today at different stages of planning and construction. Hadron therapy faces the challenge of improving treatment outcomes with tools able to provid ...
Read Project

 16

 FINISHED 

Glycomics by High-throughput Integrated Technologies (GlycoHIT)

Start date: Jan 1, 2011, End date: Jun 30, 2014,

Protein glycosylation is a post-translational phenomenon that is involved in most physiological and disease processes including cancer. Most of the known cancer-associated glycobiomarkers were discovered individually using liquid chromatography and mass spectroscopy. Though valuable, there is room for improvement in these approaches for the discovery phase. There is also a critical need for innova ...
Read Project

 16

 FINISHED 
"Autoimmune skin diseases like psoriasis and atopic dermatitis are in part CD4 T cell mediated. After stimulation, CD4 T cells differentiate into different T helper cell lineages with distinct cytokine profiles. While in atopic dermatitis for example skin infiltrating T cells mainly show a Th2-polarization, in psoriasis, which is mediated by autoreactive T cells of the Th1-phenotype, recent eviden ...
Read Project

 1

 FINISHED 
Besides a dramatic lack of financial and human resources in developing countries, health care is additionally endangered by quality deficiencies caused by low staff motivation. This lack of motivation leads to an insufficient translation of knowledge into optimal utilization of resources. The “know-do” gap represents a challenge that must be addressed to strengthen health services performance towa ...
Read Project

 6

 FINISHED 
Mosquitoes transmit a variety of infectious diseases that cause a tremendous burden to public health. Due to climate changes and to the increase in international trade and tourism the threats posed by mosquitoes are increasingly affecting large parts of Europe, causing understandable concerns among the populations of many Member States. Control methods, mainly based on insecticide usage, are strug ...
Read Project

 31

 FINISHED 
"Inherited dilated cardiomyopathies (DCM) are monogenic disorders caused by mutations in more than 30 genes, characterised by substantial phenotype heterogeneity. DCM affects 1:2.500 individuals and is the major cause of heart transplantation and death for non-ischaemic heart failure in adolescents and young adults. Currently, less than 1% of patients with familial DCM are genotyped in Europe. The ...
Read Project

 11

 FINISHED 
Brain disorders, in particular neurodegenerative diseases and mental illnesses are among the most prevalent and debilitating diseases. Because they are chronic, quality of life and socio-economic prospects are dramatically impaired. Increased life expectancy further enhances the impact of brain dysfunction on society. In coming decades this burden will grow into one of most pressing and costly pro ...
Read Project

 14

 FINISHED 
Each year Cardiovascular Disease (CVD) causes over 1.9 million deaths in the EU, causing direct health costs of €105 billion. Coronary Heart Disease (CHD), half of all CVD deaths, is the single most cause of death in Europe. Heart Failure (HF) – a CHD being the most frequent cause of hospitalization for people over 65 – has 10 million patients in the EU. Current treatment of HF entails recommendat ...
Read Project

 22

 FINISHED 

Affording Recovery In Stroke (ARISE)

Start date: Mar 1, 2008, End date: Aug 31, 2013,

"Stroke poses a massive clinical, social and economic burden, yet we have very limited effective therapies. This inadequacy is in spite of intensive research efforts and numerous failed clinical trials. Leading European stroke researchers and clinicians with a track record of established cooperation will share their complementary expertise, and team up with SME partners with high profile R&D and o ...
Read Project

 17

 FINISHED 
Cardiovascular disease (CVD) has a significant impact on the European society in terms of mortality, morbidity and allied healthcare costs. The opportunity of multi-scale modelling spanning, sub-cellular level up to whole heart is to improve CVD outcomes by providing a consistent, biophysically-based framework for the integration of the huge amount of fragmented and inhomogeneous data currently av ...
Read Project

 21

 FINISHED 

Particle Training Network for European Radiotherapy (PARTNER)

Start date: Oct 1, 2008, End date: Sep 30, 2012,

"A Particle Training Network for European Radiotherapy (PARTNER) will be established in response to the critical need for reinforcing research in ion therapy and the training of professionals in the rapidly emerging field of hadron therapy. This is an interdisciplinary, multinational initiative, which has the primary goal of training researchers who will help to improve the overall efficiency of i ...
Read Project

 10

 FINISHED 

Intervention strategies against malaria (InterMalTraining)

Start date: Oct 1, 2008, End date: Sep 30, 2012,

Malaria exacts a devastating social and economic cost across the globe. Europe is at the forefront of the battle against this disease. It contains many of the leading malaria research groups, most of which are members of at least one of two consortia; BioMalPar, a Network of Excellence focused on basic research into the biology and pathology of malaria; and AntiMal, an integrated project aiming ...
Read Project

 13