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Globally connecting single nucleotide variations to transcriptional regulation in vivo (SNPS AND TF BINDING)
Start date: Oct 1, 2009, End date: Sep 30, 2012,
Phenotype is a manifestation of a complicated relationship between the gene sequence that dictates the “what” of gene expression and regulatory elements that supply the crucial “when, where, and how.” The central components of gene regulation are transcription factors (TFs) – proteins that regulate transcription by binding to DNA regions adjacent to the gene. While TFs recognize specific DNA seque ...
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