Search for European Projects

9 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Modeling Disease through Cell Reprogramming: a Translational Approach to the Pathogenesis of Syndromes Caused by Symmetrical Gene Dosage Imbalances (DISEASEAVATARS)

Start date: Sep 1, 2014, End date: Aug 31, 2019,

The fundamental limitation in our ability to dissect human diseases is the scarce availability of human tissues at relevant disease stages, which is particularly salient for neural disorders. Somatic cell reprogramming is overcoming this limitation through the derivation of patient-specific induced pluripotent stem cells (iPSC) that can be differentiated into disease-relevant cell-types. Despite t ...
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 3

 FINISHED 

Global immunopeptidome landscape of normal and Mycobacterium tuberculosis-infected human cells (IMMUNOPEPTIDOMICS)

Start date: Sep 1, 2013, End date: Aug 31, 2015,

MHC class I-associated peptides are presented at the cell surface for scrutiny by CD8+ T lymphocytes and are collectively referred to as the immunopeptidome. The immunopeptidome plays crucial roles in many processes including autoimmunity, cancer immunosurveillance and elimination of pathogen-infected cells. Nevertheless, very little is known about the molecular composition and biogenesis of the i ...
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 1

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Systems biology of Mycobacterium tuberculosis (SYSTEMTB)

Start date: Apr 1, 2010, End date: Sep 30, 2014,

Tuberculosis (TB) is a re-emerging global health threat caused by Mycobacterium tuberculosis (Mtb). One third of the world's population is infected with Mtb and new infections occur at a rate of one per second. Despite global research efforts, mechanisms underlying pathogenesis, virulence and persistence of Mtb infection remain poorly understood. Simple reductionist approaches are insufficient to ...
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 14

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International Data Exchange and Data Representation Standards for Proteomics (ProteomeXchange)

Start date: Jan 1, 2011, End date: Jun 30, 2014,

Over the last few years the field of proteomics has evolved into a prolific data producer. As a result, various databases that collect and redistribute the acquired data have been established. While data format standards for quantitative proteomics have now been defined and implemented with significant contribution from the recently completed EU ProDaC grant, standards for quantitative proteomics ...
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 13

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Proteomics v3.0: Development, Implementation and Dissemination of a Third Generation Proteomics Technology (PROTEOMICS V3.0)

Start date: Apr 1, 2009, End date: Mar 31, 2014,

Quantitative proteomics is a key technology for the life sciences in general and for systems biology in particular. So far, however, technical limitations have made it impossible to analyze the complete proteome of any species. It is the general goal of this proposal to develop, implement, apply and disseminate a new proteomic strategy that has the potential to generate quantitative proteomic dat ...
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 1

 FINISHED 

Detecting protease substrates using unnatural amino acids (Tagging Proteolysis)

Start date: May 1, 2011, End date: Apr 30, 2013,

There are aminoacyl transferases, such as arginyl tRNA protein transferase 1 (Ate1) in Eukaryotes and leucyl/phenylalanyl tRNA protein transferase (L/F transferase) in Bacteria. Both enzymes recognize specific N-terminal amino acids of a target poly-peptide and conjugate an amino acid from an aminoacylated tRNA onto the N-terminus of the targeted poly-peptide.Ate1 conjugates an arginyl moiety ont ...
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 1

 FINISHED 

A systems approach linking genotype and environment to phenotype: oxidative stress response mechanisms in fission yeast (PhenOxiGEn)

Start date: Oct 1, 2008, End date: Mar 31, 2012,

Cellular protection against oxidative damage is relevant to ageing and numerous complex diseases. We plan to use fission yeast as a model organism to gain a systems-level understanding of the oxidative stress response and obtain insights into the interplay of variable genotype, phenotype, and environment. To this end, the four participants will pursue a range of multi-disciplinary and complementin ...
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 4

 FINISHED 

Systems Biology of Cancer Kinome (Cancer Kinome)

Start date: Oct 1, 2009, End date: Sep 30, 2011,

Protein kinases mediate most of the signal transduction events in cells by phosphorylation of specific substrates – modifying their activity, cellular location, and/or association with other proteins. The extremely critical role of kinases for critical cellular decisions came evident when an unexpectedly large number of kinases (120/518) were found to be mutationally activated activated or their e ...
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 1

 FINISHED 

A Systems Biology Approach to Elucidate the Yeast Metabolic Network (MRM-Yeast Metabolism)

Start date: May 1, 2008, End date: Apr 30, 2010,

The ultimate goal of systems biology is to generate mathematical models to comprehensively describe the dynamics of a biological system. Among all biochemical and informational systems that operate in cells, metabolism is unique because the composition and topology of the network of metabolic reactions is almost completely known. What is currently poorly understood, is how this system operates, ho ...
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 1