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2 European Projects Found

Searched on 125080 European Projects

 FINISHED 

HEMatopoietic cell IDentity : genetic and epigenetic regulation in normal and malignant hematopoiesis (HEM_ID)

Start date: Nov 1, 2011, End date: Oct 31, 2015,

In hematopoiesis, failure to maintain homeostasis and regenerative functions result in a multitude of hematological malignancies, including myelodysplastic syndromes, lymphomas and leukemias, that represent a medical challenge and a large socioeconomic burden because of the large number of affected patients of all age groups. Although hierarchical organization of the hematopoietic system has been ...
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 FINISHED 

Integrated approaches to study gene regulation during cellular differentiation (InteGeR)

Start date: Jan 1, 2009, End date: Dec 31, 2012,

Cellular differentiation from stem cells to fully functional mature cells is a multi step process executed by complex transcription programs. Once differentiated, cells must faithfully maintain their identity through cellular memory mechanisms. The utilisation of genetic information stored in linear DNA sequence occurs within the three dimensional context of chromatin, chromosomes and the nucleus, ...
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