2 European Projects Found
Searched on 125080 European Projects
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Prevalence of various genetic and epigenetic changes in genes associated with the anti-cancer drug 5-FU metabolism in patients with severe toxicity, healthy donors and various Israeli populations (5-FU PGx)
Start date: Oct 1, 2008, End date: Sep 30, 2012,
5-Fluorouracil (5-FU) has been one of the most commonly used drugs in the treatment of various types of cancer (in particular, colorectal and breast) for the past fifty years. 5-FU is a drug for which genetic and epigenetic variation in the drug-metabolizing enzyme (dihydropyrimidine dehydrogenase [DPD]) and the drug target enzyme (thymidyalate synthase [TS]) can influence both toxicity and respon ...
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Natural course, pathophysiology, models for early diagnosis, prevention and innovative treatment of TNF Receptor Associated Periodic Syndrome TRAPS with application for all hereditary recurrent fevers (EUROTRAPS)
Start date: Apr 1, 2008, End date: Sep 30, 2011,
The TNF Receptor Associated Syndrome (TRAPS) is a rare disease of innate immunity, caused by mutations in TNFR1. It is characterised by recurrent bouts of fever and pain and mainly affects patients of European ancestry. The development of renal amyloidosis in up to 20% of cases makes it a potentially fatal disease. Corticosteroids and anti-TNF therapeutics have not been consistently effective in c ...
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