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Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...

"The goal of this proposal is to develop a new strategy for asymmetric C(sp3)−H activation using a chiral base instead of chiral ligand, and will focus on oxidative addition-induced and decarboxylation-induced reactions. Using this new strategy, a wide range of representative and valuable chiral four-membered (hetero)cyclic and five-membered (hetero)cyclic organic molecules will be synthesized.Typ ...