Search for European Projects

23 European Projects Found

Searched on 125080 European Projects

 ONGOING 

RECAP: Research on European Children and Adults born Preterm (RECAP)

Start date: Jan 1, 2017, End date: Mar 31, 2021,

The project’s overall aim is to improve the health, development and quality of life of children and adults born very preterm (VPT, < 32 weeks of gestation) or very low birth weight (VLBW, < 1500g) – approximately 50 000 births each year in Europe – by establishing an ICT platform to integrate, harmonise and exploit the wealth of data from 20 European cohorts of VPT/VLBW children and adults and the ...
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 21

 ONGOING 

EURopean Endeavour for Chimeric Antigen Receptor Therapies (EURE-CART)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

Cancer is rapidly becoming the most frequent cause of death in EU. Though enormously expensive (several billions EUR/year), currently available anti-cancer therapies are major causes of chronic diseases. Adoptive immunotherapy with T cells genetically modified with a tumour-reactive chimeric antigen receptor (CAR) is an innovative therapeutic concept, promising to eradicate cancer without causing ...
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 11

 FINISHED 
Stem cell regenerative therapies hold great promise for patients suffering from a variety of disorders that are associated with tissue or organ injury. Regeneration relies on tissue or organ-specific stem and progenitor cells, but can also aim at promoting the endogenous repair capacity of the body. Mesenchymal stromal cells (MSC) are undergoing clinical testing in a variety of clinical conditions ...
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 12

 FINISHED 

My Health - My Data (MH-MD)

Start date: Nov 1, 2016, End date: Oct 31, 2019,

Issues of data subjects’ privacy and data security represent a crucial challenge in the biomedical sector more than in other industries. The current IT landscape in this field shows a myriad of isolated, locally hosted patient data repositories, managed by clinical centres and other organisations, which are subject to frequent and massive data breaches. Patients are disenfranchised in this process ...
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 16

 FINISHED 
Vancomycin is the critically important antibiotic to treat neonatal Late Onset Sepsis (LOS) due to Gram positive bacteria in neonates, including Coagulase Negative Staphylococci (CoNS) and Staphylococcus aureus. These organisms also create biofilms which are extremely resistant to antibiotics. The increased incidence of LOS due to bacteria such as CoNS and MRSA in NICUs has led to a marked increas ...
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 14

 FINISHED 
The majority of critically ill children admitted to Paediatric Intensive Care Units (PICU) will require sedation and analgesia which is commonly achieved with a combination of an benzodiazepine and an opioid. However, these agents have a significant side-effect profile, including tolerance, withdrawal and respiratory/circulatory depression. Clonidine is commonly used for sedation in PICU and recom ...
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 10

 FINISHED 
Aggression is a basic physiological trait with important roles throughout evolution, both in defence and predation. When expressed in humans in the wrong context, aggression leads to maladjustment, social impairment and crime. Despite this, knowledge about aggression aetiology is limited and current treatment strategies are insufficient. Contingent to a subdivision into impulsive and instrumental ...
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 27

 FINISHED 
DESIRE will focus on epileptogenic developmental disorders EDD, i.e. early onset epilepsies whose origin is closely related to developmental brain processes. A major cause of EDD are malformations of cortical development (MCD), either macroscopic or subtle. EDD are often manifested as epileptic encephalopathies (EE), i.e. conditions in which epileptic activity itself may contribute to severe cogni ...
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 29

 FINISHED 

Screening to improve Health In very Preterm infantS in Europe (SHIPS)

Start date: Sep 1, 2015, End date: Aug 31, 2018,

Very preterm birth is a principal determinant of motor and cognitive impairment in later life. About 50 000 infants in the EU survive very preterm birth annually and are at much higher risk of cerebral palsy, visual and auditory deficits, impaired cognitive ability, psychiatric disorders and behavioural problems than infants born at term. However, the long term prognosis at initial discharge from ...
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 15

 FINISHED 
Hemophagocytic lymphohistiocytosis (HLH) is a rare, devastating disease characterized by uncontrolled immune response that primarily affects young infants and children. HLH is usually fatal if untreated. Even when treated, the overall survival rate is still as low as 60-70%. No drug has been formally developed for the treatment of this disease and current treatment methods require the use of drugs ...
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 6

 FINISHED 

Global Research in Paediatrics (GRiP)

Start date: Jan 1, 2011, End date: Jun 30, 2017,

Paediatric drugs (PD) lack appropriate testing. Most drugs have inadequate information about dosing regimen, dose adjustment and how to administer them. These are longstanding problems that unquestionably require concerted efforts at the international level. Both the US and the EU have introduced paediatric legislation that facilitates participation of children in research and pharmaceutical innov ...
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 24

 FINISHED 

Visual Privacy Management in User Centric Open Environments (VisiOn)

Start date: Jul 1, 2015, End date: Jun 30, 2017,

Public Administration (PA) authorities are working towards upgrading the level of their online services through new governance models such as the Open Government. This pushes for greater transparency, accountability and innovation aiming at increasing citizen levels of confidence and trust in PA online services. In this context, user data privacy is an important issue. VisiOn will deliver a high T ...
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 14

 FINISHED 
Description Helping Europeans manage their weightIn some EU countries, about two in three adults and one in three children are overweight. With DAPHNE, researchers and businesses join forces to help people manage their weight and increase physical exercise using emerging technologies and information systems. The project will use a new gen ...
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 10

 FINISHED 
Though survival of children with acute lymphoblastic leukaemia (ALL) has improved, relapse remains a leading cause of mortality in childhood cancer. Given the rarity of the disease, only a large international cooperative group can recruit sufficient patients for prospective studies with specific questions in biologic subgroups. Under the umbrella of the I-BFM SG all relevant mainly European study ...
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 29

 FINISHED 

Proof of Concept of Model-based Cardiovascular Prediction (CARDIOPROOF)

Start date: Oct 1, 2013, End date: Sep 30, 2016,

CARDIOPROOF is a proof-of-concept project that consolidates the outcomes of previous VPH projects and checks the applicability and effectiveness of available predictive modelling and simulation tools, validating them in interrelated clinical trials conducted in three European centres of excellence in cardiac treatment (from Germany, Italy and the UK). CARDIOPROOF focuses on patients with aortic va ...
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 10

 FINISHED 
Primary immune deficiencies (PID) are inherited disorders of the adaptive and innate immune system marked by severe infections, autoimmunity and high risk of cancer. Treatment entails hematopoietic stem cell (HSC) transplantation from allogeneic donors, however in the absence of an HLA compatible donor, HSCT outcome is limited by delayed or suboptimal reconstitution and complications. SCID-X1 and ...
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 20

 FINISHED 
"Context: Very preterm infants face high risks of mortality and long-term neuro-developmental impairment. Rates of mortality and morbidity vary by a factor greater than two between European regions. This project’s overriding aim is to improve these infants’ survival and long-term health and development by ensuring that available medical knowledge is translated into effective perinatal care.Objecti ...
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 14

 FINISHED 
Previous studies have demonstrated the high frequency of bacterial sepsis in neonates and infants admitted to neonatal intensive care unit (NICU), often associated with serious complications or death. Many pathogens capable of causing nosocomial bacterial sepsis in neonates and young infants have developed resistance to the antibiotics considered of choice for treatment. Meropenem is an antibiotic ...
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 12

 FINISHED 

Paediatric European Risperidone Studies (PERS)

Start date: May 1, 2010, End date: Apr 30, 2015,

"Second-generation antipsychotics are increasingly being prescribed to children and adolescents. Their use, however, is mostly off-label, and adequate and sufficient data about efficacy and particular safety are lacking. This proposal focuses on two indications, the use of risperidone in children and adolescents with conduct disorder who are not mentally retarded, and the use of risperidone in ado ...
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 22

 FINISHED 
Leukodystrophies (LDs) are inherited rare neurodegenerative diseases of the white matter and its main component, the myelin, that are affecting predominantly children. Severity of the disease is related to the axonal dysfunction due to myelin deficiency or destruction. Despite the achievement of remarkable advances made in the past decade, there is no current curative therapy. The development of t ...
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 25

 FINISHED 
There is a high demand for patient specific cardiovascular disease therapeutics. Paediatric cardiology, in particular, faces difficult challenges due to the evolving nature of a child's heart and vascular system. Comprehensive and accurate computer models reconstructed from patient specific data and simulated physical constraints are needed to help determine better and more reliably risk stratific ...
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 9

 FINISHED 

Written language processing in Hearing and Deaf (WoRHD)

Start date: Oct 1, 2008, End date: Sep 30, 2011,

An issue dominating the current debate in the field of written language processing concerns the existence of brain areas dedicated to the visual perception of words. Cohen et al. (2002) suggested that such visual specialization occurs in occipito-temporal region of the left hemisphere, namely at the ‘Visual Word Form Area’ (VWFA). Using Magnetoencephalography (MEG) and presenting words and anagram ...
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 2

 FINISHED 
This medium-sized collaborative project will document and monitor the natural course and study the pathophysiology of Primary Antibody Deficiencies (PAD). PADs are rare inborn errors of the immune system with an estimated incidence of
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 13