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Crystallographic studies of the complex between the prokaryotic ribosome and the SecYEG translocon (RIBOSOME-SECYEG)
Start date: Nov 7, 2007, End date: Nov 6, 2009,
We propose to crystallize the complex of the prokaryotic ribosome or its 50S subunit with the SecYEG translocon. Two SecYEG heterotrimers bind to the ribosome at the end of the nascent polypeptide tunnel to form a transmembrane channel which is part of a translocase complex that allows for secreted and membrane embedded molecules to be transcribed through or into the membrane bilayer respectively. ...
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