5 European Projects Found
Searched on 125080 European Projects
FINISHED
Modulation of neocortical microcircuits for attention (AttentionCircuits)
Start date: Feb 1, 2014, End date: Jan 31, 2019,
At every moment in time, the brain receives a vast amount of sensory information about the environment. This makes attention, the process by which we select currently relevant stimuli for processing and ignore irrelevant input, a fundamentally important brain function. Studies in primates have yielded a detailed description of how attention to a stimulus modifies the responses of neuronal ensemble ...
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Dynamic Predictions: It's all Rhythms (THEPREDICTIVEBRAIN)
Start date: Oct 15, 2012, End date: Apr 28, 2017,
This proposal aims to elucidate the neuronal mechanism serving the human brain’s predictive capacities. Despite the wide and growing consensus on the importance of predictions in behavior and in brain functioning, the underlying neuronal mechanisms are largely unknown. Recent empirical results suggests that predictions are embodied in the temporal structure of both stimulus-evoked and ongoing acti ...
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Orchestrating the Transcriptome and Proteome in Time and Space: Quantitative Modeling of Protein Production, Degradation and Localization in Mammalian Systems (EXPRESSION DYNAMICS)
Start date: Jan 1, 2014, End date: Mar 1, 2017,
Gene expression in mammalian cells is tightly controlled and depends on the interplay between the production, degradation and localization of RNA and proteins. Each of these processes is highly regulated, but it remains largely unclear which of these is the dominant process determining the final concentration of each protein in each cell state or time point on a genomic scale.In my outgoing phase, ...
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Synaptic activity effects on local protein synthesis and spreading in high resolution (DENDRYTE TRANSLATION)
Start date: Apr 1, 2014, End date: Mar 31, 2016,
Understanding how and where our memory is stored is a long sought-after task. It is accepted that proteins at synapses play a role in capturing and maintaining memory. It is now clear that synapses possess the capacity for local protein synthesis, and that dendritic protein synthesis is required for many forms of long-term synaptic potentiation (LTP) and plasticity.It remains unclear over what spa ...
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Synaptic stability and modifiability:protein synthesis and degradation in neurons (NEURONALPROTEOSTASIS)
Start date: Mar 1, 2014, End date: Feb 29, 2016,
Control of neuronal protein homeostasis (proteostasis) is critical under both normal and abnormal synaptic function. Neuronal synapses possess 100-500 protein species that range in their copy number at individual synapses from 10-100+ copies. In order to maintain synaptic function it is clear that there must be tight regulation of protein synthesis, degradation and trafficking. In neuronal dendri ...
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