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"There is an urgent need to better understand the basic biology of Clostridium as a prerequisite for both countering the diseases they cause (C.difficile, C.perfringens and C.botulinum), and exploiting their beneficial properties in industry (biofuels by C.acetobutylicum) and medicine (cancer therapy by C.sporogenes). Attainment of this goal is being impeded because: (i) European research efforts ...

"Clostridium diffficile is currently wreaking havoc within European health systems due to the emergence of hyper virulent strains, responsible for more severe disease, higher relapse rates, increased mortality and greater resistance to antibiotics. Its impact in healthcare settings is considerable, in terms of morbidity, mortality and financial cost However, the physiological basis of pathogenesis ...