Search for European Projects

Over 40 European Projects Found

Searched on 125080 European Projects

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Molecular Nanomagnets at Surfaces: Novel Phenomena for Spin-based Technologies (MOLNANOMAS)

Start date: Jan 1, 2011, End date: Dec 31, 2015,

Molecular nanomagnets, also known as Single Molecule Magnets (SMMs), are a class of molecules that at low temperature exhibit magnetic hysteresis of pure molecular origin and not related to a cooperative effect. In the past fifteen years they have attracted great interest for their potentiality to act as magnetic memory units and for the many quantum effects in the dynamics of their magnetization ...
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New Molecular-Functional Imaging Technologies and Therapeutic Strategies for Theranostic of Invasive Aspergillosis (MATHIAS)

Start date: Oct 1, 2013, End date: Sep 30, 2018,

...isting systemic antifungal drugs with their known severe side effects. The approach of the consortium is to develop new disease specific tracers based on monoclonal antibodies along with the combined molecular imaging technologies PET/MR and PET/CT. Newly developed tracers shall then be functionalised by a combined labelling with radio-isotopes allowing diagnostic PET imaging but also immuno-radio ...
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Transforming industrial agrichemical research through the development of novel chemical tools and technologies to investigate molecular interactions (NexGenAgriChem)

Start date: Mar 1, 2014, End date: Feb 28, 2018,

...disciplinary researchers who are able to work at the interface of the Plant and Physical Sciences - a cohort who will underpin the development of novel tools and technologies that are able to provide molecular insight into the mode of action of agrichemicals.The NexGenAgriChem IDP framework directly addresses this training challenge, and will transform the landscape of rational agrichemical design ...
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Developing minimally invasive, tools and technologies for high throughput, low cost molecular assays for the early diagnosis of schizophrenia and other psychiatric disorders (SchizDX)

Start date: Oct 1, 2008, End date: Mar 31, 2012,

Schizophrenia and bipolar affective disorder are a major burden to affected individuals and their families and to society at large. These two severe mental illnesses affect at least 2% of the population worldwide, and whilst 50% of sufferers do not receive adequate treatment, they cost hundreds of billions in healthcare provision, treatments and lost earnings. The current diagnosis of schizophreni ...
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Operational characterization of quantum correlations (OPERACQC)

Start date: May 1, 2015, End date: Apr 30, 2017,

...group. As a member of the CNQO group, and especially through the collaboration with the supervisor Prof A. J. Daley, which is directed to the study and verification of quantum correlations in Atomic, Molecular, and Optical (AMO) physical systems, Dr Piani will develop and apply his expertise to AMO physics at the highest international level.
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Biochar for Carbon sequestration and large-scale removal of greenhouse gases (GHG) from the atmosphere (EUROCHAR)

Start date: Jan 1, 2011, End date: Jun 30, 2014,

...ction. Physico-chemical properties of Biochar will be analysed in a series of laboratory studies that will use standardized analytical protocols, and a specific phyto-toxicity test will be made using molecular approaches involving a model plant. Part of the study will also address the short versus long-term stability of Biochar using recently produced and aged charcoal samples coming from archaeol ...
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Microbial networks for PAC cycling in polluted soils (NETPAC)

Start date: Jun 16, 2015, End date: Jun 15, 2018,

... biodegradation, and their adaptations to low bioavailability conditions, to further exploit them in novel and more sustainable approaches for biologically mediated restoration of PAH-impacted soils. Molecular microbial ecology and analytical chemistry methods in combination with stable isotope tracers will allow a systems biology insight into the complex microbial metabolic networks dealing with ...
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Identification of genes linked to gum quality in the gum producing gum arabic tree - Acacia senegal (L.) Willd using the association genetics approach (ASGEN)

Start date: Apr 6, 2010, End date: Apr 5, 2011,

...ing demand for reliable high quality gum producing Acacia senegal. This is because the existing natural woodland based systems show considerable variability in gum quality. As well as the established molecular markers (AFLPs and SS Rs), the "ASGEN" study will employ the novel and innovative approach of association genetics in order to identify markers that are linked to gum quality or genes respon ...
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Detailed chemical kinetic models for cleaner internal combustion engines (CLEAN-ICE)

Start date: Dec 1, 2008, End date: Nov 30, 2013,

...but also innovative surrogates, describing the complex chemistry of new environmentally important bio-fuels. At the level of individual reactions rate constants, generalized rate constant classes and molecular data will be enhanced by using techniques based on quantum mechanics and on statistical mechanics. Experimental data for validation will be obtained in well defined laboratory reactors by u ...
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Microfluidic Crystal Factories (μ-CrysFact): a breakthrough approach for crystal engineering (microCrysFact)

Start date: Sep 1, 2016, End date: Aug 31, 2021,

...emicals and materials that are important for industry as well as society as a whole (e.g., drugs, superconductors, polarizers and/or frequency modulators). Despite the impressive progress made in molecular engineering during the last few decades, the quest for a general tool-box technology to study, control and monitor crystallisation processes as well as to isolate metastable states (dynamic capt ...
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Tumor Infiltrating Myeloid Cell Compartment (TIMCC)

Start date: Nov 1, 2012, End date: Oct 31, 2016,

...s underlying pro- versus anti-tumor programming of neoplastic tissues by these immune cells remain obscure.The ITN TIMCC aims to improve anti-tumor therapy by defining general and tumor type specific molecular and cellular immunological pathways (e.g signal transduction and downstream effector pathways) in tumor development and during therapeutic intervention based on an extensive analysis of the ...
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Synaptic dysfunction in Neurodegenerative Diseases (SYNDEGEN)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

...multidisciplinary approaches the SYNDEGEN consortium aims to bring together leading experts in cell biology, synapse biology and imaging, stem cell biology and NDDs in Europe to determine the molecular and cellular mechanisms whereby synapses become dysfunctional in AD, PD and HD for the purpose of developing novel therapies. The goal of the consortium is to train talented young scientists in inte ...
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The role of chromatin modifier protein hDaxx and its interaction partners in intrinsic resistance to virus infection (Cellular antivirals)

Start date: Jun 1, 2010, End date: May 31, 2012,

...of normal and mutant forms of the protein, this project will define the sequence motifs and interaction partners of hDaxx that are required for its antiviral activity. A detailed understanding of the molecular mechanisms involved in hDaxx mediated repression, and the way in which its activity is counteracted by viral regulators, may reveal novel avenues for the treatment of herpesvirus infections.
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Cardio Renal Paradigms ElucidateD through an International Exchange ScheMe (CARPEDIEM)

Start date: Jan 1, 2014, End date: Dec 31, 2017,

... own. Combining our strengths we can now address in a systematic, collaborative and multidisciplinary way the association, induction and reversibility of hypoxia, identify/relate gene expressions and molecular mechanisms in pathological signalling and by using large animal models, computational modelling and imaging in humans translate towards the clinic.This joint international research exchange ...
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Non-coding RNAs and their role in developmental networks (ncRNAsDevNet)

Start date: Mar 1, 2013, End date: Feb 28, 2015,

...sion in a specific tissue during its development taking a genomic and bioinformatics approach. In addition, since long non-coding RNAs often recruit chromatin-remodeling complexes, we will assess the molecular complexes of selected long ncRNA using biochemical mass-spec based approach. Finally, for a number of selected ncRNA, we will assess their function and requirement for mesoderm development, ...
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Public Private Partnership for Asthma Imaging and Genomics (P3AGI)

Start date: Aug 1, 2009, End date: Jul 31, 2013,

...A 2. Identification of potential biomarkers useful for clinical monitoring of therapeutic efficacy of novel compounds in ththe treatment of severe AA 3. Development of novel high resolution molecular imaging techniques in animal models of AA 4. Bioinformatics support in the acquisition, management, archiving, and analysis of imaging and genomics data
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The dynamics of the mammalian epigenome during transcription factor-induced cell fate conversion (3Dconvert)

Start date: May 1, 2015, End date: Apr 30, 2017,

...ent and difficult to translate into medical applications. The low conversion frequency in current systems, such as classic reprogramming to ‘induced’ pluripotent stem (iPS) cells, has precluded a molecular study of the critical early conversion events. We propose an interdisciplinary, exhaustive and unbiased approach to unravel the molecular events that accompany cell fate conversion processes, in ...
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NANOStructure Photochemistry via Hot Electron driven REactions (NANOSPHERE)

Start date: Mar 15, 2015, End date: Mar 14, 2017,

...unction with metal nanoparticles to demonstrate a novel and malleable approach to nanoparticle self-assembly, resulting in structures that will be used in light driven chemical reactions and advanced molecular sensing. This represents an important area of research, for whilst nanoparticles and assembled nanostructures show promise in a wide variety of applications, their uptake into current techno ...
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Mechanisms of retrotransposition in humans and consequences on cancer genomic plasticity (RETROGENOMICS)

Start date: Jan 1, 2010, End date: Dec 31, 2014,

...ransposon copy number? This will be achieved by combining functional genomics and proteomics approaches to identify positive and negative regulators of retrotransposition in humans. (ii) What are the molecular mechanisms of retrotransposons replication? To answer this question, we will develop a cell-free assay that will contain the complete retrotransposition machinery. (iii) How retrotransposons ...
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Systems biology approaches to cervical pre-cancer and cancer (SYSTEMCERV)

Start date: Nov 1, 2012, End date: Oct 31, 2014,

..., multi-content diagnostic approaches and results in reducing the number of colposcopic events. Cytology specimens will be of greater clinical utility and will result in earlier detection of disease. Molecular characterization of CIN lesions provides a basis for re-definition of histological categories.
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Spintronics with Topological Insulator/Ferromagnet Nanodevices (STIFNANO)

Start date: Apr 1, 2014, End date: Mar 31, 2016,

...thered with commonly studied heavy metals. A further objective is to investigate new magnetoresistive effects mediated by TIs surface states.We will fabricate layered FM/TI and FM/metal structures by molecular beam epitaxy and implement electrical transport and magnetic resonance measurements. The helical nature of surface states in TIs is expected to provide alternative mechanisms to produce SOTs ...
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Predictive models and simulations in nano- and biomolecular mechanics: a multiscale approach (PREDMODSIM)

Start date: Oct 1, 2009, End date: Sep 30, 2014,

The predictive ability of current simulations of interesting systems in nano- and biomolecular mechanics is questionable due to (1) uncertainties in material behavior of continuum models, (2) severe limitations of atomistic simulations in the computationally accessible length and time scales in relation with the scales of scientific and technological interest, and (3) the limited understanding gai ...
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Advanced Training in Industrial Enzyme Manufacturing (ATRIEM)

Start date: Oct 1, 2012, End date: Sep 30, 2016,

... Netherlands) to deliver a European Industrial Doctorate (EID) programme entitled: Advanced Training in Industrial Enzyme Manufacturing (ATRIEM). The PhD students will obtain high-quality training in molecular and cellular microbiology techniques and will gain relevant work and research experience in an industrial environment. The aim is to ensure that the advance technologies learnt in academia a ...
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Microcystin Exposure Associated Toxicity (MEAT)

Start date: Jun 22, 2012, End date: Jun 21, 2016,

...on is critical. In this study we will (1) undertake a series of in-lake mesocosm studies to explore thresholds and triggers of up-regulation of MC. Samples will be analyzed using a suite of sensitive molecular (QPCR, RT-QPCR, metagenome analysis), immunological and chemical techniques in concert with physical and geochemical measurements , (2) undertake a series of field-experiments, incl. the San ...
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Molecular architecture of adaptive diffusion in sibling allopolyploid lineages (Dactylorhiza, Orchidaceae) (TransAdaptation)

Start date: Dec 20, 2012, End date: Dec 19, 2014,

Hybridization and genome doubling regularly stimulate plant diversification and speciation. Immediately following a polyploidization event, a genome suffers adjustments in organization and function at the genetic and epigenetic levels. These alterations have the potential to induce novel expression patterns, which together with permanent heterozygosity and gene redundancy, might result in signific ...
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Standardisation and improvement of generic pre-analytical tools and procedures for in vitro diagnostics (SPIDIA)

Start date: Oct 1, 2008, End date: Mar 31, 2013,

... and (b) its scale is restrained to the cellular level. To address this first point, this IP, SPIDIA, built of clinicians, academics, tool and assay developers, aims to develop quality guidelines for molecular in vitro diagnostics and to standardize the pre-analytical workflow in related procedures. Regarding the second point, SPIDIA aims to develop modern pre-analytical tools for diagnostics impr ...
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Continuous measurements of plankton and environmental variables: towards assessment of phytoplankton community response to environmental change (CONPLANK)

Start date: Aug 1, 2013, End date: Jul 31, 2016,

...escales. Continuous planktonic and oceanographic high-frequency time series obtained with high technology sensors will be combined with a detailed statistical analysis of the measured time series and molecular analysis of phytoplankton biodiversity. Further research as proposed here is needed for a better understanding and prediction of coastal ecosystem responses to environmental change, which is ...
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Marine meiofauna diversity explored using environmental DNA sequencing (MARMEDIV)

Start date: Jun 1, 2010, End date: May 31, 2012,

...meiobenthos and their ecological importance recently became clear. Meiobenthos also hosts some evolutionary important albeit enigmatic phyla which diversity is almost unknown. In this project, modern molecular methods such as DNA barcoding coupled with environmental massive sequencing technologies will be used to investigate the diversity of the meiobenthos. The main objective of this study will b ...
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Unravelling the enigmatic origin of venom secreting cells in sea anemone (TentaclesOfVenom)

Start date: May 1, 2015, End date: Apr 30, 2017,

...gies, in situ hybridization and immunostaining; test the biochemical activities (pharmacological assays) of the major and novel toxins identified; and examine the phylogenetic histories and the molecular evolutionary regimes of the major sea anemone toxins to understand the recruitment of genes into the envenoming function in one of the first venomous animals.
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Photovoltaic Excitonic Solar Cells (Excitonic Solar Cell)

Start date: Jun 1, 2010, End date: May 31, 2012,

... infrared (IR) regime, and the power conversion efficiency could be improved with the use of the IR portion above 1.1 micron. This paper proposes the development of radically new nanostructures and molecular materials for the production of innovative solar cells, called excitonic solar cells (XSCs), competitive with traditional energy sources. The goals of the research are to develop XSCs using of ...
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Marine Metagenomics for New Biotechnological Applications (MAMBA)

Start date: Jul 1, 2009, End date: Jun 30, 2013,

...s. Project builds up on the scientific and technological excellence of individual academic and industrial partners, and beyond that, on application of the state-of-the-art technologies for archiving, molecular screening for the activities (using a unique Surface Plasmon Resonance screening platform), protein structure elucidation, enzyme engineering and directed evolution and establishing new biot ...
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Yeast biodiversity as a source of innovations in food and health (CORNUCOPIA)

Start date: Feb 1, 2011, End date: Apr 30, 2015,

...ng and recombinant drugs, such as insulin. S. cerevisiae is also the main model for the analysis of common features of all eukaryotic cells, and has been used in pioneering the development of several molecular biology, genomics and post-genomic tools. However, the yeast kingdom includes more than 1.500 other species that display a variety of unusual characteristics, and play an important role in t ...
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Molecular signaling of Nitric Oxide (NO) during root growth in Arabidopsis (SIGNO)

Start date: Mar 16, 2009, End date: Sep 13, 2012,

...pothesis in this proposal is that nitric oxide (NO) acts in plant developmental processes through the interaction with other plant growth regulators, such as the phytohormone auxin, using similar molecular components.The main objective of this proposal is to get insight into the nitric oxide (NO) signalling network during root growth through genetic, proteomic and genomic approaches that may let t ...
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Novel diagnostic bio-assays based on magnetic particles (BIOMAX)

Start date: Feb 1, 2011, End date: Jan 31, 2015,

...onds to the need for skilled personnel able to combine bio-assay knowledge with novel integrated device technologies. The general objective of the BioMaX network is to train the next generation of biomolecular researchers in industry and academia by establishing a pan-European network that aims at improving the career perspectives of young potentials and putting Europe at the R&D frontline in inte ...
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Rapid development and distribution of statistical tools for high-throughput sequencing data (RADIANT)

Start date: Dec 1, 2012, End date: Nov 30, 2015,

.... They include genetics of rare and common diseases, understanding of disease mechanism and progression through transcriptome and epigenome profiling, cancer stratification, personalised medicine and molecular systems biology of gene regulation. The genome, epigenome, transcriptome and interactome are all intricately connected, and modern HTS technology can probe all of these -omic levels. Statist ...
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Molecular imaging and targeted therapy of the aggressive phenotype: development of uPAR theranostics for cancer patients (uPET)

Start date: Oct 1, 2015, End date: Sep 30, 2020,

For practice of personalized medicine in cancer, non-invasive tools for diagnosing at the molecular level are needed. Molecular imaging methods are capable of this while at the same time circumventing sampling error as the whole tumor burden is evaluated.We recently developed and performed the first-ever clinical PET scan of uPAR, a proteolytic system known to be strongly associated with metastati ...
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Identification of host-factors restricting Salmonella Typhi (KILLINGTYPHI)

Start date: Apr 1, 2016, End date: Mar 31, 2018,

...oncern, claiming the lives of over 200,000 patients every year. It is caused by the intracellular bacterium Salmonella Typhi, a human-adapted pathogen unable to infect species others than humans. The molecular mechanisms underlying S. Typhi infection are only partially understood. Spanò and Galán recently discovered an antimicrobial pathway that is required to restrict the growth of S. Typhi macro ...
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Dark matter of the human transcriptome: Functional study of the antisense Long Noncoding RNAs and Molecular Mechanisms of Action (DARK)

Start date: Dec 1, 2014, End date: Nov 30, 2019,

...ense regulatory lncRNA extremely sensitive to RNA decay pathways, impinging their study so far. The roles for yeast antisense lncRNAs in shaping the epigenome raises important questions: What are the molecular and biochemical mechanisms by which antisense lncRNAs carry out their functions and are they functionally conserved in human cells? We propose that the dark side of the non-coding genome is ...
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Natural Killer Cell-Based Anti-Cancer Immunotherapies: Research training in molecular medicine and biotechnology business (NATURIMMUN)

Start date: Oct 1, 2012, End date: Sep 30, 2016,

...logy for reconstituting immune systems including NK cells in patients with hematologic cancers.All students of this ITN will be trained in state-of-the-art immunotechnology including wider aspects of molecular medicine at the individual partner universities. An exchange of students between the different partners will be organized to ensure that every participant will be trained in several laborato ...
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Mastering bioprocess Integration and intensification across scales (BIOINTENSE)

Start date: Aug 1, 2012, End date: Jan 31, 2016,

... be overcome to move towards a European Knowledge Based BioEconomy to exploit the environmental savings and economic potential if such bioprocesses were in place. Building on the recent advances in molecular biology, the time is now right to develop the necessary process engineering methodologies and implementation strategies to unlock the full potential of bioprocesses.
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