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Leukocyte migration through blood vessels and directional migration in the extravascular tissue towards sites of infection and/or injury are fundamental components of the organism’s immune response. Their inappropriate occurrence is also an important contributing factor to the development of many inflammatory conditions such as stroke and atherosclerosis. Many details of the associated mechanisms ...

Mammals have 8 distinct isoforms of PI3K. One of the key PI3K isoforms in cancer is p110a, as this isoform is extremely frequently activated by mutation. How p110a achieves this function is not clear, and my main aim is to investigate the role and mechanism of action of p110a in an oncogenic context, to provide a comprehensive picture of the molecular events controlled by p110a, and to identify m ...