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A systems biology approach to dissect cilia function and its disruption in human genetic disease (SYSCILIA)
Start date: Jun 1, 2010, End date: May 31, 2015,
AIM: To identify the molecular mechanisms characterizing cilium function, and the discrete perturbations associated with dysfunction caused by mutations in inherited ciliopathies, applying a systems biology approach. BACKGROUND: Cilia are microtubule-based, centriole-derived projections from the cell surface. They transduce extracellular signals and regulate key processes in which signals of the e ...
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