Search for European Projects

Over 40 European Projects Found

Searched on 125080 European Projects

 FINISHED 

PET Imaging in Drug Design and Development (PET3D)

Start date: Jun 1, 2016, End date: May 31, 2020,

... changing the landscape of drug design/development and improving the health care system. Positron Emission Tomography (PET) imaging, in particular, is the technology that has the potential to lead this fundamental innovation by providing at a much earlier stage reliable answers to key questions emerging during the care cycle: what and where is the disease? Is the disease accurately targeted by the ...
Read Project

 8

 FINISHED 

Hypervalent Iodine Reagents: A Tool Kit for Accessing Molecular Complexity (iTools4MC)

Start date: Jan 1, 2014, End date: Dec 31, 2018,

...oup on an organic molecule of his or her choice.An added impact of the project will be greater understanding of the reactivity of hypervalent iodine reagents and their interplay with metal catalysts, leading to unforeseen applications. This understanding can lead to the development of reactions catalytic in iodine, which can be useful not only for research, but also for the larger scale production ...
Read Project

 1

 FINISHED 

tRNA homeostasis and gene regulation (tRNA dynamics)

Start date: Aug 1, 2013, End date: Jul 31, 2015,

...g changes in tRNA abundance to apoptosis and gene misregulation in tumorigenic cells, future research on understanding how tRNA availability is regulated and how it contributes to cell survival could lead to new strategies for the rational design of molecular therapies against cancer.
Read Project

 1

 FINISHED 

Carbohydrate Mimesis using Fluorinated Sugars for Chemical Biology: From Reaction Design to Applications in Molecular Imaging (ChMiFluorS)

Start date: Nov 1, 2013, End date: Oct 31, 2018,

...tion of complex oligosaccharides containing the PET active 18F moiety. It is envisaged that by exploiting the ubiquitous role of carbohydrates in molecular recognition that this would conceivably lead to the development of selective imaging agents, thus bypassing the current problem of relying on the metabolically controlled distribution of the commonly used PET tracer 2-fluorodeoxy glucose (18F-F ...
Read Project

 1

 FINISHED 

Of DNA methylation and looping of distant regulatory elements in mantle cell lymphoma (DNAMethyLoopMCL)

Start date: Feb 1, 2014, End date: May 22, 2016,

... methylation changes in MCL that affect these processes (biological aspect); and (iii) the functional impact of differential DNA methylation between MCL subtypes (clinical aspect). The latter 2 shall lead to better understanding of the underlying molecular mechanisms of MCL and may form a basis to design new therapeutic strategies for this aggressive disease.
Read Project

 1

 FINISHED 

The role of DOT1L in regulating the epigenetic signature of cardiomyocytes during heart development (The Cardiac Code)

Start date: Jan 1, 2015, End date: Dec 31, 2017,

...esis, and in particular the role of histone methylation at lysine 79 (H3K79me) during heart development. DOT1L is the sole enzyme that catalyzes methylation at H3K79. Different degrees of H3K79me lead to distinct transcriptional readouts (gene activation, repression, or no changes of transcription) in a context dependent manner. H3K79me fluctuates during development, with Dot1L expression being hi ...
Read Project

 1

 FINISHED 

Diabetes Approach by Multi-Organ-on-a-Chip (DAMOC)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

Insulin secretion and insulin action are critical for normal glucose homeostasis. Defects in both of these processes lead to type 2 diabetes (T2D). Unravelling the mechanisms that lead to T2D is fundamental in the search of new molecular drugs to prevent and control this disease. Organ-on-a-chip devices offer new approaches for T2D disease modelling and drug discovery by providing biologically rel ...
Read Project

 1

 FINISHED 

Európán átívelő tanulmányutak a Magyar szakképzés erősítése érdekében / Study Tours across Europe for strengthening VET in Hungary

Start date: Jun 1, 2015, End date: May 31, 2016,

...d disseminate the experiences to their operation and training structure, hereby they give up-to-date knowledge to their students. The new contacts among the companies of the mentioned industries will lead to further benefits resulted by the synergy effects. By suggestions of the host organisations the dates of some travellings are adjusted to local fair events concentrated on the required fields a ...
Read Project

 3

 FINISHED 

A molecular interface science approach: Decoding single molecular reactions and interactions at dynamic solid/liquid interfaces (CSI.interface)

Start date: Jul 1, 2016, End date: Jun 30, 2021,

...quid interfaces based on well-characterized single molecular interactions. How exactly do inherently dynamic and simultaneous interactions of a countless number of interacting “crowded” molecules lead to a concerted outcome/property on a macroscopic scale? Here, I propose a unique approach that will allow us to unravel the scaling of single molecule interactions towards macroscopic properties at a ...
Read Project

 1

 FINISHED 

Mechanism of allosteric regulation of SHP2 phosphatase and its role in cancer and geneticdiseases: a multidisciplinary computational, structural and biological approach (MARS)

Start date: Apr 1, 2017, End date: Mar 31, 2019,

...a deeper understanding of SHP2 regulation, and dissect the molecular mechanisms implicated in its functional dysregulation in human disease. The planned studies are expected to provide a new class of lead compounds to treat SHP2-associated diseases. Finally, a new computational approach for the design of peptidomimetic inhibitors will be developed.
Read Project

 2

 FINISHED 

A new class of cationic lipids that activate innate immune receptors (TLR4-CAT)

Start date: Oct 1, 2013, End date: Sep 30, 2015,

...n by Toll-like receptors (TLRs), adjuvants brings the immune system in a “state of emergency” required for an efficient vaccine formulation. Knowledge of TLR-mediated signalling, therefore, could lead to rational adjuvant design for vaccines. Bacterial lipopolysaccharides (LPS), major components of the outer membrane of Gram-negative bacteria, are recognized by TLR4. Most synthetic adjuvants desig ...
Read Project

 1

 FINISHED 

Ultra-Short Pulse laser Resonators IN the Terahertz (SPRINT)

Start date: Sep 1, 2016, End date: Aug 31, 2021,

...he lithographic capability to embed miniaturized intra-cavity passive components to probe and modulate light. Graphene, owing to its gapless nature and ultrafast, gating-tunable carrier dynamic, will lead to a major breakthrough: integration in the THz QCL cavity will allow superbly manipulating its functionalities. Antenna-coupled quantum-dot nanowires will be also devised to sense and probe ultr ...
Read Project

 1

 FINISHED 

Cofactor Binding Antibodies – Basic Aspects and Therapeutic Innovations (CoBABATI)

Start date: Sep 1, 2016, End date: Aug 31, 2021,

...gical roles of cofactor-binding Abs, and 4) use cofactor binding for the development of novel types of therapeutic Abs. A comprehensive understanding of various aspects of cofactor-binding Abs should lead to advances in fundamental understanding and in the development of innovative therapeutic and diagnostic tools.
Read Project

 1

 FINISHED 

Enrichment of Components at Interfaces and Mass Transfer in Fluid Separation Technologies (ENRICO)

Start date: Oct 1, 2016, End date: Sep 30, 2021,

...ing congruence between shortcomings of the present design methods for fluid separations and the occurrence of that enrichment. It is the central hypothesis of the present research that the enrichment leads to a mass transfer resistance of the fluid interface which has to be accounted for in fluid separation process design. The fact that it is presently neglected causes unnecessary empiricism and i ...
Read Project

 1

 FINISHED 

Diagnostic and Drug Discovery Initiative for Alzheimer’s Disease (D3i4AD)

Start date: Oct 1, 2014, End date: Sep 30, 2018,

...n AD and harnessing this understanding to develop novel chemical entities for diagnostic and therapeutics applications.The D3i4AD project brings together a consortium of groups with internationally-leading expertise from academia and industries in chemistry, molecular design and modelling, biochemistry, diagnostic and drug development. Our proposed programme will lead to major increases in the kno ...
Read Project

 5

 FINISHED 

RNA-protein Nanostructures for Synthetic Biology (RNA ORIGAMI)

Start date: Apr 1, 2016, End date: Mar 31, 2021,

Synthetic biology aims at re-engineering organisms for practical applications by designing novel biomolecular components, networks, and pathways. The field is expected to lead to cheaper drugs, sustainable fuel production, efficient diagnosis and targeted therapies for diseases. However, a major obstacle to achieve these goals is our limited ability to rationally design biomolecular structure and ...
Read Project

 1

 FINISHED 

Structural, genetic and functional analyses of broadly neutralizing antibodies against human pathogens (BROADimmune)

Start date: Oct 1, 2015, End date: Sep 30, 2020,

The overall goal of this project is to understand the molecular mechanisms that lead to the generation of potent and broadly neutralizing antibodies against medically relevant pathogens, and to identify the factors that limit their production in response to infection or vaccination with current vaccines. We will use high-throughput cellular screens to isolate from immune donors clonally related an ...
Read Project

 1

 FINISHED 

Biomimetic Copper Complexes for Energy Conversion Reactions (Cu4Energy)

Start date: May 1, 2015, End date: Apr 30, 2020,

... activity and the potential energy surface of the catalytic cycle. The proposal is in particular focused on the rate-determining step of the catalytic reaction, as improvements here will directly lead to enhanced catalytic rates. A functional model system of Laccase will be designed to study the rate limiting proton-and-electron-coupled O–O bond scission reaction, which is the rate limiting step i ...
Read Project

 1

 FINISHED 

Mode of action and selectivity of pyrethroids on economically important mites and ticks (PyNaMite)

Start date: Sep 1, 2012, End date: Aug 31, 2014,

...ar. In the UK, mites have been reported in 72 % of farm stores, 81 % of commercial grain stores, 89 % of animal feed mills and 89 % of oilseed rape stores. The damage caused by a mite infestation can lead to direct financial loss through the deterioration of food quality, downgrading of products, customer complaints and rejection of stock.Synthetic pyrethroid compounds are frequently used as acari ...
Read Project

 1

 FINISHED 

Vibronic control of organic electronic devices (VIBCONTROL)

Start date: Jun 1, 2015, End date: May 31, 2020,

...r methodology will become a tool for elucidating current pathways in organic nanodevices and offer access to non-equilibrium phenomena down to the level of molecular junctions. This research will lead to the development of new design rules for OE materials serving future advances in molecular electronics, computing and sensing.
Read Project

 1

 FINISHED 

Clonal evolution in acute leukemia: from molecular and functional profiling towards therapeutic intervention (CEVAL)

Start date: Apr 1, 2013, End date: Mar 31, 2018,

...cation and selection allows cancer cells to pass through distinct steps of transformation. More recently has emerged the concept that ""more malignant"" leukemia subclones can persist after treatment leading to relapse. My research is focused on two diseases which represent privileged models to study clonal evolution: Fanconi anemia (FA), which is a genetic condition predisposing to acute leukemia ...
Read Project

 1

 FINISHED 

Crystal surface simulations (CRYSURFSIM)

Start date: Jan 3, 2012, End date: Jan 2, 2014,

...ynamic Simulations (MDS), Lattice Dynamic Simulations (LDS) and Monte Carlo Simulations (MCS). This innovative approach to balance different crystal growth models with atomistic simulations will lead towards a harmonized model, by which crystal surface processes and crystal morphologies can be simulated satisfactorily."
Read Project

 1

 FINISHED 

In Vitro and in Vivo Screens for Novel Regulators in Leukemia (NOREL) (NOREL)

Start date: Apr 1, 2012, End date: Mar 31, 2014,

"Leukemic cells, similar to other types of cancer cells, are characterized by aberrant epigenetic changes, which often lead to abnormal expression of oncogenes and tumor suppressor genes. The goal of this project is to identify and characterize new regulators of normal and malignant hematopoiesis. We propose two complementary loss-of-function screens, using shRNA vectors against two groups of hist ...
Read Project

 1

 FINISHED 

Sugar Alcohol based Materials for Seasonal Storage Applications (SAM.SSA)

Start date: Apr 1, 2012, End date: Mar 31, 2015,

...overcome by the materials proposed in SAM.SSA.SAM.SSA will develop molecular alloys based on sugar alcohols (MASA). These molecular alloys allow for adjustment of the melting point and lead to a significantly increased energy density compared not only to that of their components, but also to that of n-alkanes molecular alloys. Furthermore sugar alcohols permit high levels of undercooling thus min ...
Read Project

 9

 FINISHED 

MODeling the EnviRonmental and human health effects of Nanomaterials (MODERN) (MODERN)

Start date: Jan 1, 2013, End date: Dec 31, 2015,

Nano-sized materials are a common element in many industrial processes mainly due to their unique properties that lead to the production of high technology products. The widespread use of nanotechnology requires the consideration of the environmental and human health risks that may result from the introduction of engineered nanoparticles (eNPs) into the environment. Although toxic effects for cert ...
Read Project

 7

 FINISHED 

Molecular basis of the outer membrane permeability (TRANSLOCATION)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

...a data base to allow the sharing of antibacterial R&D information on an unprecedented level. Also, via careful analysis of this information we intend to provide learnings as best practices that will lead to an increase in the overall efficiency of antibacterial R&D.
Read Project

 28

 FINISHED 

Novel Insights into Multi-drug Resistance to Antibiotics and the Primordial Ribosome (NOVRIB)

Start date: Feb 1, 2013, End date: Jan 31, 2018,

...designing autonomous molecular entities with catalytic capabilities. Constructs the bind substrates have already been obtained. The expected enhancement in understanding peptide bond formation should lead to novel insights into this universal essential process. Our studies are designed to provide unprecedentedly powerful new tools for minimizing pathogens resistance thus should be of immense thera ...
Read Project

 1

 FINISHED 

Star-like Oligo(aniline)s with Tunable Band Gaps for Tailored Nanostructures in Advanced Electronic Applications (TANOGAPPs)

Start date: Jul 29, 2013, End date: Jul 28, 2015,

...c self-assembly technique. Controlling the molecular architecture and acids dopants will allow for tuning of and controll over band gaps, physical dimensions and localized defects. This approach will lead to optimised nanostructured morphologies and ensure efficient charge separation and transport. As a result, enhanced mobility, sensitivity and selective interactions with external stimuli will of ...
Read Project

 1

 FINISHED 

Identification of new colorectal cancer susceptibility genes (Finding CRC genes)

Start date: Jun 17, 2013, End date: Jul 6, 2017,

...CRC is one of the most important causes of morbidity and mortality in occidental countries. An early diagnosis of CRC as well as clinical surveillance of those with an increased risk to develop a CRC leads to an important decrease of CRC morbidity and mortality. Genetic diagnosis is a powerful tool to detect at risk patients, and although some genes have been demonstrated to cause CRC, they explai ...
Read Project

 1

 FINISHED 

User-driven Development of Statistical Methods for Experimental Planning, Data Gathering, and Integrative Analysis of Next Generation Sequencing, Proteomics and Metabolomics data (STATegra)

Start date: Oct 1, 2012, End date: Sep 30, 2015,

...biomedical users as beta-testers.To deliver beyond current exploratory tools, our consortium accumulates the necessary strong statistical, technological, and molecular expertise. The strong lead by research intensive SMEs, with proven track-record in software deployment, translates STATegra to a wide existing community base. STATegra accelerates the production of relevant statistical tools impacti ...
Read Project

 11

 FINISHED 

Computational Exploration of Directed Evolution rules for tuning enzymatic activities (DIREVENZYME)

Start date: Mar 1, 2014, End date: Feb 28, 2018,

... but limit the choices using statistical methods. Still, tens of thousands of variants need to be tested experimentally. In addition to that, little information is available as to how these mutations lead to enhanced enzyme proficiency. Significant advances in computational tools have enabled the de novo design of enzymes catalyzing unnatural reactions making use of the so-called inside-out comput ...
Read Project

 1

 FINISHED 

Engineered Protein Capsids as Artificial Bacterial Organelles (EPCABO)

Start date: Mar 1, 2013, End date: Feb 28, 2018,

...evolve redox active organelles for metabolizing aliphatic alcohols; and (e) engineer artificial organelles for the detoxification of polychlorinated phenols. We anticipate that these experiments will lead to a deeper understanding of the principles underlying the construction, function and evolution of natural protein microcompartments. At the same time, they will establish powerful strategies for ...
Read Project

 1

 FINISHED 

Architecture and logic of the eukaryotic cell cycle (SYNTHECYCLE)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

...stigate the rationale behind the complexity in cell cycle control observed in modern cells, as my previous work has demonstrated that entire branches of the network are dispensable. This will finally lead us to take a unique approach to explore evolutionary principles, assessing how cells operating with simplified CDK circuits adapt and overcome defects in cell cycle progression.These studies rely ...
Read Project

 1

 FINISHED 

"Scandium-based multifunctional nitrides for optoelectronic, polaritonic and ferro/magnetoelectric devices" (SCOPE)

Start date: Nov 1, 2012, End date: Oct 31, 2017,

...ly pumped full-spectrum polaritonic lasers, and (3) developing an optimised artificial synapse for adaptive computing (plus similar related non-volatile memory devices). Combined, such advances could lead towards the “spintronics dream” of devices with integrated optoelectronic, photonic and magnetic functionality. Importantly, the mature growth and device processing technologies in place for conv ...
Read Project

 2

 FINISHED 

Solid State Chameleons: Chemical Transformations as Single Crystal Transitions (SCSCT)

Start date: Jan 3, 2013, End date: Jan 2, 2015,

"This project aims to identify and exploit the properties of crystalline molecular materials that lead to single crystal to single crystal transformations (SCSCT). Chemical reactions involving bond formation and breaking generally do not proceed as SCSCT because of the significant structuralrearrangement involved in the process. There exists a small class of compounds for which this phenomenon is ...
Read Project

 1

 FINISHED 

Parallel computing based on designed networks explored by self-propelled, biological agents (ABACUS)

Start date: Jan 1, 2014, End date: Dec 31, 2016,

...rge numbers of biological agents. Key aims of the project will be the benchmarking against existing computational approaches, and the identification of application areas where this novel paradigm may lead to transformative applications. Benefits to society will include the ability to solve hitherto intractable problems, and the development of a sustainable and energy-efficient computing approach t ...
Read Project

 5

 FINISHED 

Quantum scattering at ultracold temperatures: a few S-matrix columns is all we need (SUPERCOLD)

Start date: Sep 1, 2013, End date: Aug 31, 2015,

...ion. Our approach is expected to answer many challenging questions on the success of cooling techniques to go below microKelvin temperatures, assist researchers in the design of novel experiments and lead to high-impact publications.The project is designed as a collaborative effort involving researchers from 5 institutions in as many EU states. The main work will be carried out in O Dulieu's group ...
Read Project

 1

 FINISHED 

Uncovering the molecular and cellular mechanism of tumor dormancy for the rational design of theranostic nanomedicines (PolyDorm)

Start date: Apr 1, 2014, End date: Mar 31, 2019,

...ablished interaction of tumor cells with their surrounding microenvironment. Failure of a microscopic tumor, either primary, recurrent or metastatic, to complete one or more of these early stages may lead to delayed clinical manifestation of the cancer and a state of stable non-progressing disease. Micrometastasis, dormant tumors, and residual tumor cells contribute to the occurrence of relapse, a ...
Read Project

 1

 FINISHED 

Transforming industrial agrichemical research through the development of novel chemical tools and technologies to investigate molecular interactions (NexGenAgriChem)

Start date: Mar 1, 2014, End date: Feb 28, 2018,

...lants, whilst mitigating competition for water and land use. The Foresight report on Global Food and Farming Futures (2011), the most comprehensive food security study to date, involved more than 400 leading experts from 35 different countries who concluded that the current global food system is failing. This landmark document highlighted that targeted investment in agricultural research and innov ...
Read Project

 2

 FINISHED 

Selective Carbon-Carbon Bond Activation: A Wellspring of Untapped Reactivity (CMetC)

Start date: Nov 1, 2013, End date: Oct 31, 2018,

...h selective C-C bond activation. Ideally, alkenes will be in-situ transformed into alkanes that will subsequently undergo the C-C activation even in the presence of functional group. This work will lead to ground-breaking advances when non-strained cycloalkanes (cyclopentane, cyclohexane) will undergo this smooth C-C bond activation with friendly and non toxic organometallic species.
Read Project

 1