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Functional characterization of FAN1, a structure-specific DNA repair nuclease (FanDamAge)
Start date: May 1, 2013, End date: Apr 30, 2015,
DNA interstrand crosslinks (ICLs) are toxic lesions, which prevent the separation of strands necessary for DNA replication. ICLs arise in cells when common endogenous metabolites react with DNA and when cells are exposed to commonly used chemotherapeutic drugs, such as mitomycin-C (MMC) and cisplatin. Defects in the repair of endogenous ICLs cause Fanconi anaemia, characterized by chromosome insta ...
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