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The importance of Nef effects on HIV-1 infectivity for viral pathogenesis (Nef-pathogenesis)
Start date: Jul 1, 2009, End date: Jun 30, 2011,
The AIDS epidemic remains a worldwide emergency and the molecular mechanisms leading to the disease are not fully understood. Nef is a gene product of primate lentiviruses crucial for virus replication in vivo and for AIDS progression. The mechanisms supporting its pathogenic role remain undefined. Among other activities, Nef enhances intrinsic virus infectivity, a feature well conserved and under ...
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