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"Amines and their acylated derivatives – amides – are among the most common chemical functional groups found in modern pharmaceuticals. Despite this there are few methods for their efficient, environmentally sustainable production in enantiomerically pure form. This proposal seeks to provide new catalytic chemical methods including 1) the catalytic, enantioselective synthesis of peptides and 2) ca ...

A new class of reagents for directly accessing more drug like molecules at the early stages of drug development will be developed. This technology is based on a new method to easily prepare saturated N-heterocycles, which have proven advantages in drug like molecules but are difficult to prepare at the early stages of lead discovery and optimization. The key reactions and reagent has been validate ...