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Elucidation of a microRNA turnover machinery in C. elegans (miRT)
Start date: Mar 1, 2008, End date: Feb 28, 2010,
MicroRNAs (miRNAs) are a large class of noncoding regulatory RNAs. In animals miRNAs base-pair with the 3’ untranslated region (UTR) of their target mRNAs to target them for cleavage or translational repression. Repressed target mRNAs accumulate in cytoplasmic structures termed P-bodies, where some targets may be degraded. Other targets appear to be stable and can subsequently be re-expressed. In ...
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