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CHARACTERIZATION OF THE B-CELL-SPECIFIC GENE REGULATORY NETWORK BY GENOME-WIDE IDENTIFICATION OF DIRECT PAX5 TARGET GENES (PAX5TARGETS)
Start date: Mar 1, 2008, End date: Feb 28, 2010,
"A complex network of transcription factor interactions controls the process by which B lymphocytes develop from hematopoietic stem cells (HSCs). Pax5 has been identified as the critical transcription factor controlling B cell commitment throughout B lymphopoiesis. These analyses revealed that Pax5 commits early hematopoietic progenitors to the B cell pathway by repressing B-lineage-inappropriate ...
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