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The role of DOT1L in regulating the epigenetic signature of cardiomyocytes during heart development (The Cardiac Code)
Start date: Jan 1, 2015, End date: Dec 31, 2017,
Understanding mechanisms underlying cardiomyocyte (CM) transcriptional regulation is critical for deciphering molecular origins of cardiac malformations. Epigenetics is crucial for stabilizing transcriptional programs, but little is known about the “epigenetic code” of histone methylation during cardiogenesis, and in particular the role of histone methylation at lysine 79 (H3K79me) during heart de ...
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